2-Fluoroethanol

64.06

64.06

1730857

206-740-2

4M427A5HML

158283

2929|2642

DTXSID0059902

2905590090

20.2

-0.67

Ethylene fluorohydrin appears as a liquid. Used as a rodenticide, insecticide and acaricide. Not registered as a pesticide in the U.S. (EPA, 1998)

1.1040 g/cm³ @ Temp: 20 °C

-26.4 °C

103.5 °C

88 °F

1.326

Fully miscible.

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

16 mm Hg ( 20 °C)

No rapid reaction with air. No rapid reaction with water.

Alcohols and Polyols

ETHYLENE FLUOROHYDRIN generates very toxic fumes of fluoride that will be emitted in a fire. [EPA, 1998].

I

6.1

UN 3383 6.1/PG 1

3

10-26/27/28-36/37/38

36/37/39-45-23-16

KL1575000

T+,T,F

P260-P264-P280-P284-P301 + P310-P302 + P350

H226-H300 + H310 + H330

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

USEPA; Chemical Profile: Ethylene fluorohydrin (1985)

Very toxic fumes of fluoride may be emitted in a fire. (EPA, 1998)|Flammable - 3rd degree

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. LARGE FIRE: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Avoid inhalation and skin contact. (Non-Specific -- Fluoroacetic Acid) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Ethylene fluorohydrin is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 10 lbs.

Ethylene fluorohydrin's production and use in non-US areas as a rodenticide, insecticide, and acaricide will result in its direct release to the environment(SRC). It is not registered for use as a pesticide in the United States(2).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that ethylene fluorohydrin is expected to have very high mobility in soil(SRC). Volatilization of ethylene fluorohydrin from moist soil surfaces is expected to be an important fate process(SRC) based on the estimated Henry's Law constant of 7.1X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(3). The potential for volatilization of ethylene fluorohydrin from dry soil surfaces may exist(SRC) based upon a vapor pressure of 21.25 mm Hg(4).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that ethylene fluorohydrin is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.4X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are calculated to be 3 days and 33 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3.2(SRC),from its log Kow of -0.67(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low.|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene fluorohydrin, which has a vapor pressure of 21.25 mm Hg at 25 °C(2) is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase ethylene fluorohydrin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 days(SRC), calculated from its rate constant of 2.2X10-12 cu cm/molecule-sec at 25 °C(3).

The rate constant for the vapor-phase reaction of ethylene fluorohydrin with photochemically-produced hydroxyl radicals has been estimated as 2.2X10-12 cu cm/molecule-sec at 25 °C(SRC), calculated using a structure estimation method(1). This corresponds to an atmospheric half-life of about 7 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Ethylene fluorohydrin is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2) nor to directly photolyze due to the lack of absorption in the environmental UV spectrum.

An estimated BCF of 3 was calculated for ethylene fluorohydrin using a measured log Kow of -0.67(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for ethylene fluorohydrin can be estimated to be about 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that ethylene fluorohydrin is expected to have very high mobility in soil.

The Henry's Law constant for ethylene fluorohydrin is estimated as 7.1X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). The value for the Henry's Law constant indicates that ethylene fluorohydrin is expected to volatilize from water surfaces(2). Based on the Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 3 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 33 days(SRC). Ethylene fluorohydrin's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of ethylene fluorohydrin from dry soil surfaces may exist(SRC) based upon a vapor pressure of 21.25 mm Hg(3).

Occupational exposure to ethylene fluorohydrin may occur through inhalation and dermal contact with this compound at workplaces where ethylene fluorohydrin is produced or used. (SRC)

Absorbed promptly from the alimentary tract ... absorption does not occur through intact skin. /Fluoroacetate/

The fluoroacetate ion is not poisonous itself but is converted to fluorocitric acid, which blocks the tricarboxylic acid cycle, an essential mechanism of energy production in mammalian cells ... This manifests itself principally in disturbed activities of the central nervous system and of the heart. /Fluoroacetate/

Toxicity rating is the same as for fluoroacetate, super toxic. The probable oral lethal dose in humans is a taste (less than 7 drops) for a 70 kg (150 lb.) person. The chemical is highly toxic when inhaled or absorbed through the skin. Toxicity depends on its oxidation to fluoroacetate by tissue alcohol dehydrogenase. (EPA, 1998)

Warning: Highly toxic when inhaled or absorbed through the skin. Delayed convulsant. Effects usually appear within 30 minutes of exposure but may be delayed as long as 20 hours. Caution is advised. Vital signs should be monitored closely. Signs and Symptoms of Ethylene Fluorohydrin Exposure: Signs and symptoms may be extremely severe and range from nausea, excessive salivation, vomiting, diarrhea, blurred vision, tingling sensations, and muscular weakness and twitching to convulsions alternating with coma and depression, and heart failure. Other symptoms include numbness, low blood pressure, hyperactivity, respiratory depression or arrest, cyanosis (blue tint to the skin and mucous membranes), and ventricular fibrillation. Emergency Life-Support Procedures: Acute exposure to ethylene fluorohydrin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to ethylene fluorohydrin. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 4. Rush to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to ethylene fluorohydrin. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Remove contaminated clothing and shoes as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 7. Rush to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 2. Obtain authorization and/or further instructions form the local hospital for performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of ethylene fluorohydrin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 5. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of ethylene fluorohydrin may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 5.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Rush to a health care facility. (EPA, 1998)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Monofluoroacetate and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Monofluoroacetate and related compounds/

In a nonfatally poisoned infant only mild emesis and sinus tachycardia preceded four brief episodes of seizure activity over a 12 hr period that began 20 hr after ingestion; recovery was uneventful thereafter. /Fluoroacetate/|An 18-month-old girl with repeated convulsions died in coma 96 hr after ingesting an estimated 23 mg/kg fluoroacetamide. /Fluoroacetate/|SYMPTOMATOLOGY: 1. Prompt epigastric distress and vomiting in one reported case. 2. Apprehension, auditory hallucinations, nystagmus, tingling sensation of nose, facial twitching, numbness of face. These and other central nervous effects appear gradually after a latency of several hours. 3. Central nervous excitation, progressing to epileptiform convulsions. 4. Severe central nervous depression between and subsequent to the convulsive episodes, but death is seldom due to respiratory failure in humans poisoned with fluoroacetate. 5. Disturbances in the mechanism of the heart beat usually appear only after the convulsive phase. 6. Pulse alternans, long sequences of ectopic beats (often multifocal), and ventricular tachycardia may disintegrate into ventricular fibrillation and death. /Fluoroacetate/

2-fluoroethanol

Ethanol, 2-fluoro-: ACTIVE|It is not registered for use as a pesticide in the United States.

Fire Hazards -> Flammable - 3rd degree