Heptafluorobutyric anhydride
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Heptafluorobutyric anhydride
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CAS No:
336-59-4
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Formula:
C8F14O3
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Chemical Name:
Heptafluorobutyric anhydride
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Synonyms:
Butanoic acid,2,2,3,3,4,4,4-heptafluoro-,1,1′-anhydride;Butyric acid,heptafluoro-,anhydride;Butanoic acid,heptafluoro-,anhydride;Heptafluorobutyric anhydride;Perfluorobutyric anhydride;Heptafluorobutyric acid anhydride;Heptafluorobutyryl anhydride;Perfluorobutanoic anhydride;Heptafluorobutanoic anhydride;HFBA;2,2,3,3,4,4,4-Heptafluorobutanoyl 2,2,3,3,4,4,4-heptafluorobutanoate
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CAS No:
Description
clear colorless liquid
Heptafluorobutyric anhydride is an acyclic carboxylic anhydride that is perfluorinated butyric anhydride. It is used as a derivatising reagent for gas chromatographic analyses. It has a role as a chromatographic reagent. It is an organofluorine compound and an acyclic carboxylic anhydride. It derives from a butyric acid.
Safety Information
III
8
UN 3265 8/PG 2
3
R34
S26-S36/37/39-S45
C:Corrosive;
P280-P305 + P351 + P338-P310
H314
|Danger|H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]|P280, P305+P351+P338, and P310
Drug Information
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)
heptafluorobutyric anhydride
Heptafluorobutyric anhydride Use and Manufacturing
As a GC derivatizing agent, Heptafluorobutyric anhydride is used to prepare volatile derivatives of amino acids and other biologically active compounds.
Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970).
HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.
suzuki reaction
Butanoic acid, 2,2,3,3,4,4,4-heptafluoro-, 1,1'-anhydride: ACTIVE
PFAS (per- and polyfluoroalkyl substances) -> OECD Category
Computed Properties
Molecular Weight:410.06
XLogP3:4.8
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:6
Exact Mass:409.9623881
Monoisotopic Mass:409.9623881
Topological Polar Surface Area:43.4
Heavy Atom Count:25
Complexity:493
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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