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Home > Encyclopedia > Pseudoephedrine hydrochloride

Pseudoephedrine hydrochloride

Pseudoephedrine hydrochloride structure

Pseudoephedrine hydrochloride 

structure
  • CAS No:

    345-78-8

  • Formula:

    C10H15NO.ClH

  • Chemical Name:

    Pseudoephedrine hydrochloride

  • Synonyms:

    Benzenemethanol,α-[(1S)-1-(methylamino)ethyl]-,hydrochloride (1:1),(αS)-;Pseudoephedrine,hydrochloride,(+)-;Pseudoephedrine hydrochloride;Benzenemethanol,α-[1-(methylamino)ethyl]-,hydrochloride,[S-(R*,R*)]-;Benzenemethanol,α-[(1S)-1-(methylamino)ethyl]-,hydrochloride,(αS)-;d-[α-(1-Methylamino)ethyl]benzyl alcohol hydrochloride;d-Pseudoephedrine hydrochloride;L-(+)-Pseudoephedrine hydrochloride;(+)-Pseudoephedrine hydrochloride;1S,2S-(+)-Pseudoephedrine hydrochloride;Sudafed;Novafed;(1S,2S)-(+)-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride;CPDD 0050;d-(1S,2S)-Pseudoephedrine hydrochloride;Sinufed;Galpseud;Otrinol;Rhinalair;Symptom 2;NSC 106567;NSC 33634;Decongess SR;6272-89-5

  • Categories:

    Active Pharmaceutical Ingredients  >  Respiratory Drugs

Description

white powder


Pseudoephedrine Hydrochloride is the hydrochloride salt form of pseudoephedrine, a phenethylamine and an diastereomer of ephedrine with sympathomimetic property. Pseudoephedrine hydrochloride displaces norepinephrine from storage vesicles in presynaptic neurones, thereby releasing norepinephrine into the neuronal synapses where it stimulates primarily alpha-adrenergic receptors. It also has weak direct agonist activity at alpha- and beta- adrenergic receptors. Receptor stimulation results in vasoconstriction and decreases nasal and sinus congestion.|A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.

Pseudoephedrine hydrochloride Basic Attributes

201.69

201.09200

206-462-1

6V9V2RYJ8N

759616|106567|33634

C29390

2922199090

Characteristics

32.26000

2.52080

190-191 °C

255ºC at 760mmHg

85.6ºC

Refrigerator (+4°C)

LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles)

61 º (c=5, H2O,2dm tube)

132.1 Ų [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

III

6.1(b)

1544

3

22-36/37/38-36/38-39/23/24/25-23/24/25-11

26-36-24/25-45-36/37-16-7

UL5950000

Xn,T,F

P301 + P312 + P330-P305 + P351 + P338

H302-H315-H319

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 302 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

Ephedrine Threo Isomer

Pseudoephedrine hydrochloride Use and Manufacturing

Uses

Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.

Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride (1:1), (.alpha.S)-: ACTIVE

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:201.69
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:201.0920418
Monoisotopic Mass:201.0920418
Topological Polar Surface Area:32.3
Heavy Atom Count:13
Complexity:121
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Nasal mucosal vasoconstrictor that relieves nasal congestion

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • MALLADI DRUGS AND PHARMACEUTICALS LTD

    United States United States
    Active
  • EMBIO LIMITED

    India India
    Active
  • CHENG FONG CHEMICAL CO., LTD.

    Taiwan, China Taiwan, China
    Active

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