Pseudoephedrine hydrochloride
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Pseudoephedrine hydrochloride
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CAS No:
345-78-8
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Formula:
C10H15NO.ClH
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Chemical Name:
Pseudoephedrine hydrochloride
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Synonyms:
Benzenemethanol,α-[(1S)-1-(methylamino)ethyl]-,hydrochloride (1:1),(αS)-;Pseudoephedrine,hydrochloride,(+)-;Pseudoephedrine hydrochloride;Benzenemethanol,α-[1-(methylamino)ethyl]-,hydrochloride,[S-(R*,R*)]-;Benzenemethanol,α-[(1S)-1-(methylamino)ethyl]-,hydrochloride,(αS)-;d-[α-(1-Methylamino)ethyl]benzyl alcohol hydrochloride;d-Pseudoephedrine hydrochloride;L-(+)-Pseudoephedrine hydrochloride;(+)-Pseudoephedrine hydrochloride;1S,2S-(+)-Pseudoephedrine hydrochloride;Sudafed;Novafed;(1S,2S)-(+)-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride;CPDD 0050;d-(1S,2S)-Pseudoephedrine hydrochloride;Sinufed;Galpseud;Otrinol;Rhinalair;Symptom 2;NSC 106567;NSC 33634;Decongess SR;6272-89-5
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CAS No:
Description
white powder
Pseudoephedrine Hydrochloride is the hydrochloride salt form of pseudoephedrine, a phenethylamine and an diastereomer of ephedrine with sympathomimetic property. Pseudoephedrine hydrochloride displaces norepinephrine from storage vesicles in presynaptic neurones, thereby releasing norepinephrine into the neuronal synapses where it stimulates primarily alpha-adrenergic receptors. It also has weak direct agonist activity at alpha- and beta- adrenergic receptors. Receptor stimulation results in vasoconstriction and decreases nasal and sinus congestion.|A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.
Pseudoephedrine hydrochloride Basic Attributes
201.69
201.09200
206-462-1
6V9V2RYJ8N
759616|106567|33634
C29390
2922199090
Characteristics
32.26000
2.52080
190-191 °C
255ºC at 760mmHg
85.6ºC
Refrigerator (+4°C)
LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles)
61 º (c=5, H2O,2dm tube)
132.1 Ų [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
III
6.1(b)
1544
3
22-36/37/38-36/38-39/23/24/25-23/24/25-11
26-36-24/25-45-36/37-16-7
UL5950000
Xn,T,F
P301 + P312 + P330-P305 + P351 + P338
H302-H315-H319
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 302 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)
Ephedrine Threo Isomer
Pseudoephedrine hydrochloride Use and Manufacturing
Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.
Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride (1:1), (.alpha.S)-: ACTIVE
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:201.69
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:201.0920418
Monoisotopic Mass:201.0920418
Topological Polar Surface Area:32.3
Heavy Atom Count:13
Complexity:121
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Nasal mucosal vasoconstrictor that relieves nasal congestion
Registered Holders
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MALLADI DRUGS AND PHARMACEUTICALS LTD
Active
United States
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EMBIO LIMITED
Active
India
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CHENG FONG CHEMICAL CO., LTD.
Active
Taiwan, China
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