1H-Indole-2-carboxylic acid, 5-fluoro-, ethyl ester

light yellow powder

500 grams of polyphosphoric acid and 250 grams of phosphoric acid mixed, stirring under heating to 75 ° C under the conditions of which by adding raw materials 4-fluorophenylhydrazine pyruvate phenyl hydrazone 65 grams, control the temperature range of 75 ~ 85 , 1 hour to complete the raw materials, continue to control the temperature reaction for 20 minutes to complete the monitoring reaction, pour 1500 grams of ice water mixture, cooling, drying and drying to obtain light yellow solid product, drying to get 5 - fluoroindole - 2 - carboxylic acid Ethyl ester 52.2 g, yield 87percent5-Fluoro-1H-indole-2-carboxylic acid 11a (853mg, 4.76mmol) was dissolved in 40mL of absolute ethanol, 8mL of 98percent concentrated sulfuric acid was added, the reaction solution was heated to reflux for 2 hours. 250mL of water was added to the reaction solution, the pH was adjusted to 7 to 8 with 1M NaOH, the solution was extracted with ethyl acetate (250mL*3). 5-Fluorondole-2-carboxylic acid (5.00g, 27.91mmol) was added to ethanol (50mL) at 0 °C. SOClGeneral procedure: To a stirred solution of the appropriate acid (5 or 6) (11.16 mmol) in EtOH (60 mL) was added dropwise thionyl chloride (13.40 mmol) and the mixture was heated under reflux for 3 h. After cooling, water was added till a precipitate appeared. The crude product was filtered and dried over reduced pressure.1.1. Ethyl 1-

Reactant for preparation of antitumor agents 1 Reactant for preparation of antihyperlipidemic agents 2 Reactant for preparation of factor Xa inhibitors 3 Reactant for preparation of potential antiarrhythmic agents 4 Reactant for preparation of inhibitors of the cytosolic phospholipase A2 5 Reactant for preparation of thromboxane receptor antagonist and thromboxane synthase inhibitor via Mitsunobu reaction 6

Molecular Weight:207.20
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:207.06955672
Monoisotopic Mass:207.06955672
Topological Polar Surface Area:42.1
Heavy Atom Count:15
Complexity:247
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes