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Home > Encyclopedia > 2-Ethoxyethyl acrylate

2-Ethoxyethyl acrylate

2-Ethoxyethyl acrylate structure

2-Ethoxyethyl acrylate 

structure
  • CAS No:

    106-74-1

  • Formula:

    C7H12O3

  • Chemical Name:

    2-Ethoxyethyl acrylate

  • Synonyms:

    2-Propenoic acid,2-ethoxyethyl ester;Acrylic acid,2-ethoxyethyl ester;Ethanol,2-ethoxy-,acrylate;Cellosolve acrylate;Ethylene glycol monoethyl ether acrylate;Ethylene glycol monoethyl ether propenoate;2-Ethoxyethyl acrylate;A-EE;NSC 72733;NSC 8390;EM 211;2-Ethoxyethyl propenoate

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

2-Ethoxyethyl acrylate Basic Attributes

144.168

144.17

203-429-3

32X1O435SV

72733|8390

DTXSID3051545

2916129000

Characteristics

35.53000

1.02

0.983 g/cm3 @ Temp: 20 °C

-47 °C

174 °C

62.7±14.4 °C

1.420

The effectiveness of phenolic inhibitors is dependent on the presence of oxygen and the monomers must be stored under air rather than an inert atmosphere. Temp must be kept low to minimize formation of peroxides and other products. ... The acrylic esters may be stored in mild or stainless steel, or aluminum. /Acrylic acid & derivatives/

1.19mmHg at 25°C

React readily with electrophilic, free-radical, and nucleophilic agents. /Acrylic acid & esters/

Safety Information

UN 2810

R36/37/38;R51/53

S26;S28;S61

Xi: Irritant;N: Dangerous for the environment;

P210, P264, P270, P280, P301+P312, P302+P352, P312, P322, P330, P363, P370+P378, P403+P235, P501

H227

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P264, P270, P280, P301+P312, P302+P352, P312, P322, P330, P363, P370+P378, P403+P235, and P501

SUITABLE PROTECTIVE CLOTHING & SELF-CONTAINED RESP PROTECTIVE APPARATUS SHOULD BE AVAILABLE FOR USE OF THOSE WHO MAY HAVE TO RESCUE PERSONS OVERCOME BY FUMES. /ACRYLIC ACID & DERIVATIVES/|Protection required for safe handling of acrylic acid and esters commonly includes use of impervious gloves, shoe soles, and clothing; splash-proof goggles ... . /Acrylic acid & derivatives/

Awareness of the dangers and of good engineering design are essential to safety. Employees should be instructed about the necessity of cleansing the skin if it is contaminated by materials which are irritants or skin-absorbed. With careful design, however, and complete enclosure of those processes where toxic chemicals or intermediates occur, dangerous exposures can be avoided. /Acrylic acid & derivatives/|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

THE LOWER-MOL-WT ESTERS OF ACRYLIC ACIDS ARE IRRITANTS TO SKIN, EYES, & MUCOUS MEMBRANES. /ACRYLIC ACID ESTERS/|A skin and severe eye irritant.

Toxicity

LD50 Rat oral 1070 mg/kg|LD50 Rabbit skin 1010 mg/kg

Drug Information

THE AVAILABLE DATA INDICATE THAT ... /LOW MOLECULAR WEIGHT OXYGENATED ACRYLATES/ ARE READILY SAPONIFIED AND METABOLIZED IN THE MAMMALIAN SYSTEM. /OXYGENATED ACRYLATES/

Basic treatment: Establish a patent airway. Suction if necessary. Encourage patient to take deep breaths. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Irritating materials/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Irritating materials/

THE ACUTE TOXICITY OF THE ACRYLATES DECREASES WITH INCREASING MOLECULAR WEIGHT. ... HUMAN SIGNS & SYMPTOMS FOLLOWING INGESTION OF ACRYLIC MONOMERS INCL COLLAPSE, SEVERE RESPIRATORY DIFFICULTIES, & CNS STIMULATION. ACUTE INHALATION OF HIGHER CONCN MAY CAUSE MARKED IRRITATION, SALIVATION, CONJUNCTIVAL IRRITATION, & PRONOUNCED PULMONARY IRRITATION OR EDEMA. PROLONGED SKIN OR EYE CONTACT MAY RESULT IN SEVERE TISSUE DAMAGE. THE PATHOLOGY FROM SINGLE EXPOSURE IS NONSPECIFIC, CONTRARY TO REPEATED EXPOSURE EFFECTS, WHICH INCL PULMONARY CONGESTION OR HEMORRHAGE & CLOUDY SWELLING OF LIVER & KIDNEY. /ACRYLATES/

2-Ethoxyethyl acrylate Use and Manufacturing

Methods of Manufacturing

TRANSESTERIFICATION OR ESTERIFICATION OF ETHOXYETHANOL WITH EITHER METHYL ACRYLATE OR ACRYLIC ACID|Acrylates can be prepared by ... dehydration of the corresponding hydroxyalkanoic acid, saponification of the alkene nitrile, catalytic hydration of acetylene and carbon monoxide, or the reaction of acetone with hydrocyanic acid. /Acrylates/|In ... propylene oxidation process acrolein is first formed by the catalytic oxidation of propylene vapor at high temp in the presence of steam. The acrolein is then oxidized to acrylic acid. ... The acrylic acid is esterified with alcohol to the ... acrylic ester in a separate process. /Acrylic ester monomers/

Uses

MONOMER FOR SPECIALTY ELASTOMERS-EG, ADHESIVES, LAMINATES|In elastomers

... Hydroquinone or monomethyl ether hydroquinone are added to acrylic monomers to stabilize them ... . /Acrylic ester monomers/

2-Propenoic acid, 2-ethoxyethyl ester: ACTIVE

Chemical assay is preferably performed by gas-liquid chromatography or by the conventional methods for determination of unsaturation such as bromination or addition of mercaptan, sodium bisulfide, morpholine, or mercuric acetate. /Acrylic acid & derivatives/|RETENTION TIMES FOR ACRYLATES WERE MEASURED WITH 2 DIFFERENT COLUMNS (C18 CORASIL & C8 LICHROSORB) USING REVERSE-PHASE HIGH PRESSURE LIQ CHROMATOGRAPHY IN ORDER TO OBTAIN THE PARTITION COEFFICIENTS OF ACRYLATES BETWEEN 1-OCTANOL AND WATER (LOG P). /ACRYLATES/

Computed Properties

Molecular Weight:144.17
XLogP3:0.7
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:144.078644241
Monoisotopic Mass:144.078644241
Topological Polar Surface Area:35.5
Heavy Atom Count:10
Complexity:109
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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