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Alipamide

Alipamide structure

CAS No:
3184-59-6
Formula:
C9H12ClN3O3S
Chemical Name:
Alipamide
Synonyms:
D-1721;CI-546;Alipamid;Alipamide;Alipamidum;4-Chloro-N',N'-dimethyl-3-sulfamoylbenzohydrazide;2-chloro-5-(dimethylaminocarbamoyl)benzenesulfonamide
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Alipamide is a hydrazide derivative of m-sulfamoylbenzoic acid with diuretic activity. Alipamide primarily causes a saluretic effect and is able to inhibit carbonic anhydrase at higher doses which may also contribute to this agent's diuretic effect.

Alipamide Basic Attributes

Molecular Weight：

277.723

Exact Mass：

277.02900

UNII：

PE8925K9EY

DSSTox ID：

DTXSID40185704

NCI Thesaurus Code：

C81071

HScode：

2935009090

Characteristics

PSA：

101

XLogP3：

2.54970

Density：

1.428g/cm3

Melting Point：

185-188 °C(Solv: water (7732-18-5))

Refractive Index：

1.589

Alipamide Use and Manufacturing

Diuretic; antihypertensive.

Computed Properties

Molecular Weight:277.73
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:277.0287901
Monoisotopic Mass:277.0287901
Topological Polar Surface Area:101
Heavy Atom Count:17
Complexity:379
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes