2-(Trichloromethyl)oxirane
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2-(Trichloromethyl)oxirane
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CAS No:
3083-23-6
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Formula:
C3H3Cl3O
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Chemical Name:
2-(Trichloromethyl)oxirane
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Synonyms:
Oxirane,2-(trichloromethyl)-;Propane,1,1,1-trichloro-2,3-epoxy-;Oxirane,(trichloromethyl)-;2-(Trichloromethyl)oxirane;3,3,3-Trichloropropylene oxide;1,1,1-Trichloro-2,3-epoxypropane;1,1,1-Trichloro-2-propene oxide;3,3,3-Trichloro-1,2-epoxypropane;3,3,3-Trichloropropene oxide;1,1,1-Trichloropropane 2,3-epoxide;1,1,1-Trichloropropene 2,3-oxide;1,1,1-Trichloropropylene oxide;1,2-Epoxy-3,3,3-trichloropropane;Trichloropropene oxide;1,1,1-Trichloropropene oxide;1,1,1-Trichloropropane 2,3-oxide;TCPO;(Trichloromethyl)oxirane;NSC 136558;122763-35-3
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CAS No:
Description
colourless liquid
1,2-epoxy-3,3,3-trichloropropane is a clear colorless liquid. (NTP, 1992)
1,2-epoxy-3,3,3-trichloropropane is a clear colorless liquid. (NTP, 1992)|A potent epoxide hydrase and aryl hydrocarbon hydroxylase inhibitor. It enhances the tumor-initiating ability of certain carcinogens.
Characteristics
12.53000
1.75540
1,2-epoxy-3,3,3-trichloropropane is a clear colorless liquid. (NTP, 1992)
1.4921 g/cm3 @ Temp: 25 °C
149 °C
64.3ºC
1.535
less than 0.1 mg/mL at 65.3° F (NTP, 1992)
11.6 mm Hg at 77° F ; 28.5 mm Hg at 108° F; 65.5 mm Hg at 149° F (NTP, 1992)
mmo-sat 740 mg/plate APSXAS 17,189,80
Insoluble in water.
Halogenated Organic Compounds
Polymerizable
Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts.
Safety Information
Stable. Combustible. Incompatible with strong oxidizing agents.
This chemical is combustible. (NTP, 1992)
|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
1,1,1-Trichloropropene-2,3-oxide
2-(Trichloromethyl)oxirane Use and Manufacturing
Trichloropropene Oxide is a epoxide hydratase inhibitor and possess potential carcinogenic properties.