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Home > Encyclopedia > N-Acetylaspartylglutamic acid

N-Acetylaspartylglutamic acid

N-Acetylaspartylglutamic acid structure

N-Acetylaspartylglutamic acid 

structure
  • CAS No:

    3106-85-2

  • Formula:

    C11H16N2O8

  • Chemical Name:

    N-Acetylaspartylglutamic acid

  • Synonyms:

    L-Glutamic acid,N-acetyl-L-α-aspartyl-;L-Glutamic acid,N-(N-acetyl-L-α-aspartyl)-;Glutamic acid,N-(N-acetyl-L-aspartyl)-,L-;N-Acetyl-L-α-aspartyl-L-glutamic acid;N-Acetyl-α-aspartylglutamic acid;N-Acetylaspartylglutamic acid;N-Acetyl-α-L-aspartyl-L-glutamic acid;Isospaglumic acid;Acetyl-α-L-aspartylglutamic acid;N-(N-Acetylaspartyl)glutamic acid;α-Spaglumic acid;N-Acetyl-L-aspartyl-L-glutamic acid;NAAG;3220-76-6

  • Categories:

    Biochemical Engineering  >  Polypeptide

Description

Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.


Solid


Ac-Asp-Glu is a dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage. It has a role as a human metabolite. It derives from a N-acetyl-L-aspartic acid and a L-glutamic acid. It is a conjugate acid of an Ac-Asp-Glu(3-).

N-Acetylaspartylglutamic acid Basic Attributes

304.25

304.25

1W8M12WXYL

758468

DTXSID3091535

R - Respiratory system|S - Sensory organs

2924199090

Characteristics

170

-1.96

white powder

1.5±0.1 g/cm3

171-173 °C

769.5±60.0 °C at 760 mmHg

419.1±32.9 °C

1.540

H2O: 50 mg/mL

−20°C

166.3 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|156.77 Ų [M-H2O-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

Safety Information

NONH for all modes of transport

3

36/37/38

26-36

Xi

P261-P305 + P351 + P338

H315-H319-H335

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept. (See all compounds classified as Neurotoxins.)|Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

isospaglumic acid

N-Acetylaspartylglutamic acid Use and Manufacturing

Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.

Computed Properties

Molecular Weight:304.25
XLogP3:-2.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:304.09066547
Monoisotopic Mass:304.09066547
Topological Polar Surface Area:170
Heavy Atom Count:21
Complexity:448
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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