N-Acetylaspartylglutamic acid
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N-Acetylaspartylglutamic acid
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CAS No:
3106-85-2
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Formula:
C11H16N2O8
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Chemical Name:
N-Acetylaspartylglutamic acid
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Synonyms:
L-Glutamic acid,N-acetyl-L-α-aspartyl-;L-Glutamic acid,N-(N-acetyl-L-α-aspartyl)-;Glutamic acid,N-(N-acetyl-L-aspartyl)-,L-;N-Acetyl-L-α-aspartyl-L-glutamic acid;N-Acetyl-α-aspartylglutamic acid;N-Acetylaspartylglutamic acid;N-Acetyl-α-L-aspartyl-L-glutamic acid;Isospaglumic acid;Acetyl-α-L-aspartylglutamic acid;N-(N-Acetylaspartyl)glutamic acid;α-Spaglumic acid;N-Acetyl-L-aspartyl-L-glutamic acid;NAAG;3220-76-6
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CAS No:
Description
Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.
Solid
Ac-Asp-Glu is a dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage. It has a role as a human metabolite. It derives from a N-acetyl-L-aspartic acid and a L-glutamic acid. It is a conjugate acid of an Ac-Asp-Glu(3-).
N-Acetylaspartylglutamic acid Basic Attributes
304.25
304.25
1W8M12WXYL
758468
DTXSID3091535
R - Respiratory system|S - Sensory organs
2924199090
Characteristics
170
-1.96
white powder
1.5±0.1 g/cm3
171-173 °C
769.5±60.0 °C at 760 mmHg
419.1±32.9 °C
1.540
H2O: 50 mg/mL
−20°C
166.3 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|156.77 Ų [M-H2O-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept. (See all compounds classified as Neurotoxins.)|Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)
isospaglumic acid
N-Acetylaspartylglutamic acid Use and Manufacturing
Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
Computed Properties
Molecular Weight:304.25
XLogP3:-2.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:304.09066547
Monoisotopic Mass:304.09066547
Topological Polar Surface Area:170
Heavy Atom Count:21
Complexity:448
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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