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mikamycinB

mikamycinB structure

CAS No:
3131-03-1
Formula:
C45H54N8O10
Chemical Name:
mikamycinB
Synonyms:
PA114B;NSC92554;mikamycinB;MikaMycinIA;OstreogrycinB;StreptograminB;VirginiaMycinB;PristinamycinIA;PristinaMycinP1;AntibioticPA114B
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is

A specific streptogramin group B antibiotic produced by Streptomyces graminofaciens and other bacteria.

mikamycinB Basic Attributes

Molecular Weight：

866.95800

Exact Mass：

866.39600

NSC Number：

92554

Characteristics

PSA：

227.96000

XLogP3：

2.13220

Density：

1.38g/cm3

Melting Point：

198°

Boiling Point：

1202.1ºC at 760mmHg

Flash Point：

680.8ºC

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3172

Drug Information

MeSH Entry Terms：

4-(4-(Dimethylamino)-N-methyl-L-phenylalanine)virginiamycin S1

mikamycinB Use and Manufacturing

One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810). Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Computed Properties

Molecular Weight:867.0
XLogP3:2.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:7
Exact Mass:866.39628995
Monoisotopic Mass:866.39628995
Topological Polar Surface Area:228
Heavy Atom Count:63
Complexity:1700
Undefined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Pristinamycin IA

CAS No.: 3131-03-1

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CAS No.: 3131-03-1

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