1-Methoxy-2-methyl-2-propanol

General procedure: Typically, the required amount of catalyst (0.037 mmol of Zr)was added to a round-bottom flask (25 mL). To remove absorbedwater in the catalysts, the MOFs were pre-treated by heating themat 150C under vacuum overnight. The required amount of alco-hol was introduced (5 mL) into the flask and the system sonicatedfor 15 min. After this time, the epoxide was added (1 mmol). Sub-sequently, the reaction mixture was placed in a preheated bath bathat the required temperature (i.e. 50C) and stirred magnetically.In the case of amine after the activation of the catalyst, acetoni-trile (2.5 mL) was added as solvent, the catalyst was sonicated andfinally, the amine (1.0 mmol) and the styrene oxide (1.0 mmol)were added. At the end of the reaction the catalyst was exhaustivelywashed with methanol to recover most of the adsorbed product.Product isolation was carried out by purification with flash col-umn chromatography on silica gel using hexane: dichloromethaneas eluent. The course of the reaction was periodically followed byextracting aliquots of the reaction mixture with a syringe, dilutingin methanol and injecting the mixture immediately in GC (6890Network GC system Agilent technologies) and using a calibrationplot to determine the product concentration.

Molecular Weight:104.15
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:104.083729621
Monoisotopic Mass:104.083729621
Topological Polar Surface Area:29.5
Heavy Atom Count:7
Complexity:50
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes