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(-)-Quinine dihydrochloride

(-)-Quinine dihydrochloride structure

CAS No:
60-93-5
Formula:
C20H24N2O2.2ClH
Chemical Name:
(-)-Quinine dihydrochloride
Synonyms:
Cinchonan-9-ol,6′-methoxy-,hydrochloride (1:2),(8α,9R)-;Quinine,dihydrochloride;Cinchonan-9-ol,6′-methoxy-,dihydrochloride,(8α,9R)-;Acid quinine hydrochloride;Quinine bimuriate;(-)-Quinine dihydrochloride
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Description

White Solid

(-)-Quinine dihydrochloride Basic Attributes

Molecular Weight：

397.34

Exact Mass：

396.137146

EC Number：

200-493-4

UNII：

8C3EMH7D9X

HScode：

29392000

Characteristics

PSA：

45.59000

XLogP3：

4.71510

Appearance：

white solid

Melting Point：

238-2400C

Boiling Point：

495.9ºC at 760 mmHg

Flash Point：

253.7ºC

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Stability/Shelf Life：

Stable, but may be light sensitive. Efflorescent. Incompatible with strong oxidizing agents.

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P312, P302+P352, P321, P330, P333+P313, P363, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]

(-)-Quinine dihydrochloride Use and Manufacturing

Uses

Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal)

Manufacturing Info：

Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:2), (8.alpha.,9R)-: INACTIVE

Computed Properties

Molecular Weight:397.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:396.1371335
Monoisotopic Mass:396.1371335
Topological Polar Surface Area:45.6
Heavy Atom Count:26
Complexity:457
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

The Chinese medicine angelica in this product has the effect of promoting blood circulation and nourishing blood, cinnamon has the effect of promoting menstruation, and motherwort promotes blood circulation and regulates menstruation. Belladonna fluid extract is an anticholinergic drug with obvious peripheral anticholinergic effect, relieving smooth muscle spasm and improving microcirculation. Ferrous sulfate is the main component of hemoglobin and myoglobin, and hemoglobin is the main oxygen carrier in red blood cells. Iron supplementation can accelerate hemoglobin synthesis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Angelica Ferrous Tablets
Ingredients	This product is a compound preparation, and its components per tablet are: 0.02g of angelica; 0.01g of cinnamon; 0.0072ml of motherwort fluid extract; 0.006g of belladonna fluid extract; 0.06g of ferrous sulfate; 0.012g of quinine hydrochloride; and appropriate amount of auxiliary materials.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Shanghai Sine Tianping Pharmaceutical Co., Ltd.

Quinine dihydrochloride injection
Ingredients	The main ingredient of this product is quinine dihydrochloride, the chemical name of which is 6-methoxy (8a, 9R) cinchonis 9-ol dihydrochloride
Indication	1. Antacids and aluminum-containing preparations can delay or reduce the absorption of quinine; 2. When anticoagulants are used in combination with quinine, the anticoagulant effect can be enhanced; 3. Muscle relaxants such as succinylcholine and tubocurarine can react with quinine and may cause respiratory depression; 4. When quinidine is used in combination with quinine, the cinchona reaction can be increased; 5. Urine alkalinizing agents such as sodium bicarbonate can increase the reabsorption of quinine by the renal tubules, leading to an increase in quinine blood concentration and toxicity; 6. Combination with vitamin K can increase the absorption of quinine; 7. Combination with buclizine, cyclizine, meclizine, phenothiazines, thioxanthenes, trimethofenzamide, and aminoglycoside antibiotics can cause tinnitus and dizziness; 8. When used in combination with nifedipine (nifedipine), the concentration of free quinine increases.
Specifications	1ml:0.5g
Manufacturer	Yunnan Phyto Pharmaceutical Co., Ltd.

Quinine dihydrochloride injection
Ingredients	The main ingredient of this product is quinine dihydrochloride, the chemical name of which is 6-methoxy (8a, 9R) cinchonis 9-ol dihydrochloride
Indication	1. Antacids and aluminum-containing preparations can delay or reduce the absorption of quinine; 2. When anticoagulants are used in combination with quinine, the anticoagulant effect can be enhanced; 3. Muscle relaxants such as succinylcholine and tubocurarine can react with quinine and may cause respiratory depression; 4. When quinidine is used in combination with quinine, the cinchona reaction can be increased; 5. Urine alkalinizing agents such as sodium bicarbonate can increase the reabsorption of quinine by the renal tubules, leading to an increase in quinine blood concentration and toxicity; 6. Combination with vitamin K can increase the absorption of quinine; 7. Combination with buclizine, cyclizine, meclizine, phenothiazines, thioxanthenes, trimethofenzamide, and aminoglycoside antibiotics can cause tinnitus and dizziness; 8. When used in combination with nifedipine (nifedipine), the concentration of free quinine increases.
Specifications	1ml:0.25g
Manufacturer	Shanxi Nuocheng Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Guangdong Leawell Pharmaceutical Co., Ltd.

China
Active
Anhui Gallup Pharmaceutical Technology Co., Ltd.

China
Inactive

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Quinine dihydrochloride

CAS No.: 60-93-5

Content: 99.00%

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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Quinine dihydrochloride 98% Dideu

CAS No.: 60-93-5

Grade: Pharmaceutical Grade

Content: 98%

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Guide of (-)-Quinine dihydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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(-)-Quinine dihydrochloride

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