Octamethyltrisiloxane

236.534

236.53

203-497-4

9G1ZW13R0G

DTXSID9040710

P - Antiparasitic products, insecticides and repellents

2934999090

18.46000

4.74

Liquid

0.820 g/cm³

-80 °C

153 °C

99 °F

1.405

Solubility in water: none

Flammables area

3.34 mmHg

>1 (vs air)

30.60 atm-m3/mole

Viscosity: 41 cSt at 37.8 °C /Silicone fluid with 10 mm sq/S viscosity/|DIMETHYLPOLYSILOXANES ARE PRACTICALLY INERT POLYMERS

III

3.2

UN 1993 3/PG 3

3

10

23-24/25

Stable to heat and resistant to most chemical substances, although they are affected by strong acids.

P273-P501

H226-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P273, P280, P303+P361+P353, P370+P378, P391, P403+P235, and P501|Aggregated GHS information provided by 320 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H319 (62.57%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P273, P280, P305+P351+P338, P337+P313, P391, and P501|Aggregated GHS information provided by 1762 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

POLY(DIMETHYLSILOXANE) FLUIDS IN INTIMATE CONTACT WITH SOILS UNDERGO SILOXANE BOND REDISTRIBUTION & HYDROLYSIS RESULTING IN FORMATION OF LOW MOLECULAR WEIGHT CYCLIC & LINEAR OLIGOMERS. LOW MOLECULAR WEIGHT HYDROXYFUNCTIONAL HYDROLYSIS PRODUCTS ARE WATER SOLUBLE & CYCLICS & TRIMETHYLSILOXY-END-BLOCKED OLIGOMERS ARE VOLATILE, THUS PROVIDING MATERIALS WHICH CAN PARTITION FROM THE SOIL TO THE WATER & ATMOSPHERIC ENVIRONMENTAL COMPARTMENTS. CLAYS WERE THE CATALYTIC SOIL COMPONENT RESPONSIBLE FOR THE OLIGOMERIZATION & HYDROLYSIS REACTIONS.

Intravitreal injections of silicone oil experimentally in ... patients to replace cloudy vitreous or as an aid in treatment of retinal detachment have generally given first impressions of being well tolerated. However, cataracts have developed in ... patients.|Human eyes examined histologically years after intravitreal silicone oil injection also showed many cavities, presumably occupied by silicone oil, in most of the tissues of the eye. Phagocytic cells were seen to have taken up the oil, but without inflammatory reaction or necrosis such as would suggest a toxic process. It appeared that a portion of the injected oil became emulsified and phagocytosed in various parts of the eye.|Development of secondary open-angle glaucoma in a moderate proportion of patients after intravitreal silicone oil has been explained as due to oil-containing macrophages blocking the intertrabecular spaces of the trabecular meshwork. In two well-studied eyes with glaucoma, histology showed phagocytes with oil vacuoles in the trabecular meshwork, in a situation to block aqueous outflow.|The lower viscosity oils cause slight transient sensation of irritation when applied to ... human eyes, but no injury of the cornea. However, they delay healing of experimental corneal erosions.|For more Human Toxicity Excerpts (Complete) data for POLYDIMETHYLSILOXANES (6 total), please visit the HSDB record page.

baysilon

A typical antiperspirant stick formula is: 27.5 wt % stearic acid monoethanolamide; 24.0 wt % poly(dimethylsiloxane) (low viscosity, volatile); 20.0 wt % rehydrol powder; 15.0 wt % propoxylated myristyl alcohol; 9.0 wt % propylene glycol; 3.0 wt % distilled or deionized water; 1.0 wt % perfume; and 0.5 wt % myristyl lactate.

All other basic inorganic chemical manufacturing|Trisiloxane, 1,1,1,3,3,5,5,5-octamethyl-: ACTIVE|Polydimethylsiloxanes are practically inert polymers.

NIOSH Method: 227. Analyte: Polymethylsiloxane mist in air. Matrix: Air. Procedure: Flameless atomic absorption analysis. Method Evaluation: Method was validated over the range of 0.01 to 0.1 mg/cu m using a 400 liter sample. Method detection limit: 0.04 mg/ml or 0.001 mg/cu m. sample. Method detection limit: 0.04 mg/ml or 0.001 mg/cu m. Precision (CVT): 0.15. Interferences: Chloroform-soluble silicon compounds presumably would interfere. /Polymethylsiloxane mist in air/|Determination of volatile polydimethylsiloxane by adsorption using a charcoal column and pyrolysis GC.|Atomic absorption spectrophotometric method for determination of polydimethylsiloxane residues in pineapple juice.|Polydimethylsiloxane was determined in emulsions by extraction with org solvents (eg, MeCOBu-iso or n-hexane) and subjected to gel-permeation chromatography on a polystyrene-divinylbenzene column with toluene mobile phase. The relative standard deviation was 1.9% and a calibration graph was linear in the conc range of 0.5-2.5 mg/ml.

A simple method of extraction and determination of organosilicon oxide polymers (silicones) in 0.1-0.5 g of formalin fixed tissue by atomic absorption spectroscopy is described. Before the tissue is extracted with n-heptane, it is dried in a desiccator containing concentrated sulfuric acid. The graphite tubes in the HGA graphite furnace are tubes with L'vov platform. The evaporation of n-heptane and a part of the charing of the tissue extraction in the tube are done in the presence of O (air). The methods detection limit (2 times standard deviation) is approx 0.009 ug Si/ml tissue extraction which corresponds to approx 0.5 ug polydimethylsiloxane/g tissue.|A quant in vivo ATR/FTIR method to det the concn of ingredients on human skin was developed. The key parameters for control of the method are prism selection, skin/prism contact, and quantitation by hand ratio using the Amide II protein band from skin as an internal standard A test procedure was developed to measure soap wash resistance of polydimethylsiloxane (dimethicone) fluids. The results from these expt indicate that dimethicone substantivity increases with increasing polymer mol wt. Other personal care ingredients can also be evaluated with this technique. The primary criterion is the presence of a distinctive absorption band in the molecule's IR spectrum and, as an example, mink oil data are presented. Finally, the utility of a substantivity aid for enhancing the soap wash resistance of a personal care ingredient was demonstrated using mink oil.|Pharmaceuticals containing di-Me siloxane were refluxed with KOH and Si(OEt)4, the mixture. was cooled and distilled. The distillate was analyzed by GC on a Diasolid ZF column at injection temp of 100 deg. The recovery and relative standard deviation were 98.1 and 2.98%, respectively.

EPA Safer Chemical Functional Use Classes -> Defoamers|Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues|Cosmetics -> Skin conditioning