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Desglymidodrine

Desglymidodrine structure

CAS No:
3600-87-1
Formula:
C10H15NO3
Chemical Name:
Desglymidodrine
Synonyms:
Benzenemethanol,α-(aminomethyl)-2,5-dimethoxy-;Benzyl alcohol,α-(aminomethyl)-2,5-dimethoxy-;α-(Aminomethyl)-2,5-dimethoxybenzenemethanol;ST 1059;1-(2,5-Dimethoxyphenyl)-2-aminoethanol;Desglymidodrine;Deglymidodrine;2-Amino-1-(2,5-dimethoxyphenyl)ethanol;2-Amino-1-(2′,5′-dimethoxyphenyl)ethanol;2-Amino-1-(2,5-dimethoxyphenyl)ethan-1-ol;52047-77-5
Categories:
Organic Chemistry > Amides

Description

White Powder

Deglymidodrine is an aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states. It has a role as an alpha-adrenergic agonist, a sympathomimetic agent and a vasoconstrictor agent. It is an aromatic ether, a secondary alcohol and a primary amino compound.

Desglymidodrine Basic Attributes

Molecular Weight：

197.23

Exact Mass：

197.23

HScode：

2922509090

Characteristics

PSA：

64.7

XLogP3：

1.39620

Density：

1.145±0.06 g/cm3(Predicted)

Melting Point：

95-96 °C @ Solvent: Ethyl acetate

Boiling Point：

364.3ºC at 760mmHg

Flash Point：

174.1ºC

Refractive Index：

1.542

Storage Conditions：

-20°C Freezer

Safety Information

Transport codes：

NONH for all modes of transport

Drug Information

MeSH Entry Terms：

1-(2',5'-dimethoxyphenyl)aminoethanol

Desglymidodrine Use and Manufacturing

Uses

A metabolite of Midodrine.It induces alpha-adrenergic receptor stimulation of both arterial and venous systems without direct central nervous systme of cardiac effects

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:197.23
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:197.10519334
Monoisotopic Mass:197.10519334
Topological Polar Surface Area:64.7
Heavy Atom Count:14
Complexity:165
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 3600-87-1

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CAS No.: 3600-87-1

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Content: 99%

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