2-Ethyl-1H-indole

To a round-bottom flask was charged with 2-(2, 2-dibromo-vinyl)-phenylamine (0.139 g, 0.50 mmol), K3PO4-H2O (0.58 g, 2.5 mmol), Pd2(dba)3 (4.6 mg, 2 molpercent Pd) and s-Phos (10.3 mg, 5 molpercent). After the mixture was purged with N2 for over 10 min, triethylborane was added, followed by addition of H2O (10 muL). The reaction mixture was stirred at 60 0C for 2 h. The mixture was then cooled to -20 0C, to which H2O2 (30percent, 0.5 mL) was added. The mixture was slowly warmed to rt and stirred for another 30 min. After usual aqueous workup, the product was purified by flash chromatography on silica gel (10percent EtOAc in hexanes) to afford a crystalline product (0.108 g, 77percent) as the title product (Sadanandan, E. V.; Srinivasan, P. C. Synthesis 1992, 648-650).30a) Preparation of ... falling within the ambit of the formula 1-R8 -pyrrole and carbazole compounds falling within the ambit of the formula 9-R8 -carbazole which are useful in the practice of the processes of this invention for producing the aforesaid methanes and alkanes of Formulas I, XI and XVI....5-Methoxy-1-butylindole, 1-Allyl-2-methylindole, 1, 2-Dimethyl-6-nitroindole, 1-(4-Chlorobenzyl)-2-methyl-5-nitroindole, The following compounds are exemplary of indoles, pyrroles and carbazoles useful in the practice of this invention....1, 2-Dimethyl-6-nitroindole, 1-(4-Chlorobenzyl)-2-methyl-5-nitroindole, The following compounds are exemplary of indoles, pyrroles and carbazoles useful in the practice of this invention....5-Methoxy-1-butylindole, 1-Allyl-2-methylindole, 1, 2-Dimethyl-6-nitroindole, 1-(4-Chlorobenzyl)-2-methyl-5-nitroindole, The following compounds are exemplary of indoles useful in the practice of this invention....1-Ethyl-2-methylindole, 1-Propyl-2-methylindole, 1-Butyl-2-methylindole, 1-Octyl-2-methylindole,

Molecular Weight:145.20
XLogP3:3
Hydrogen Bond Donor Count:1
Rotatable Bond Count:1
Exact Mass:145.089149355
Monoisotopic Mass:145.089149355
Topological Polar Surface Area:15.8
Heavy Atom Count:11
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes