HydroxyaceticAcidHydrazide
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HydroxyaceticAcidHydrazide
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CAS No:
3530-14-1
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Formula:
C2H6N2O2
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Chemical Name:
HydroxyaceticAcidHydrazide
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Synonyms:
Hydroxyacethydrazide;GlicolicAcidHydrazide;2-hydroxyethanehydrazide;HydroxyaceticAcidHydrazide;2-Hydroxy-aceticAcidHydrazide
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CAS No:
HydroxyaceticAcidHydrazide Use and Manufacturing
General procedure: To a stirred solution of esters 2a–2j (70 mmol) in MeOH (30 mL) cooled in an ice-water bath was added dropwise 80percent aqueous hydrazine hydrate (6.26 g, 100 mmol). The resulting solution was stirred at room temperature (2a–2b or 2d–2j), or reflux (2c), until the completion of reaction as indicated by TLC analysis (typically within 5 h). The reaction mixture was evaporated on a rotary evaporator to give a residue, which was purified by column chromatography through a short silica gel column to yield 3a–3k after trituration with n-hexane if possible.A. 2-Hydroxyacetohydrazide. A solution of ethyl 2-hydroxyacetate ( 1.00 g, 9.60 mmol), hydrazine (0.324 mg, 10.1 mmol), and ethanol (20 mL) were combined and heated to 85 °C for 3 h. The reaction was concentrated to afford the title compound (0.702 g, 81percent). MS (ESI) m/z 91.1 [M+ 1]Preparation 69: 2-Hydroxyacetohydrazide Hydrazine monohydrate (1.08 g, 22.2 mmol) was added to a solution of methyl glycolate (0.84 mL, 11.1 mmol) in methanol (10 mL) and the mixture was heated under reflux for 2 hours and stirred at room temperature for 72 hours. The reaction mixture was then concentrated in vacuo to afford the title compound as a white solid in quantitative yield.
Computed Properties
Molecular Weight:90.08
XLogP3:-1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:90.042927438
Monoisotopic Mass:90.042927438
Topological Polar Surface Area:75.4
Heavy Atom Count:6
Complexity:53.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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