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2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine

2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine structure

CAS No:
3546-03-0
Formula:
C19H21N3S
Chemical Name:
2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine
Synonyms:
10H-Phenothiazine-2-carbonitrile,10-[3-(dimethylamino)-2-methylpropyl]-;Phenothiazine-2-carbonitrile,10-[3-(dimethylamino)-2-methylpropyl]-;10-[3-(Dimethylamino)-2-methylpropyl]-10H-phenothiazine-2-carbonitrile;7204 RP;10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile;Cyamemazine;Cyamepromazine;2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine;R.P. 7204;TH 2602;Kyamepromazine;Cianatil;Cyamemazin;F. I. 6229;7204 R. E.;Cyamepromezine;Ciamatil;Tercian;119805-49-1

Description

Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].

Cyamemazine is a member of phenothiazines.|Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an atypical antipsychotic, due to its potent anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-HT2A).

2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine Basic Attributes

Molecular Weight：

323.458

Exact Mass：

323.46

EC Number：

222-594-2

ATC Code：

N - Nervous system

HScode：

2934300000

Characteristics

PSA：

55.6

XLogP3：

4.62

Density：

1.2±0.1 g/cm3

Melting Point：

204-205

Boiling Point：

205-220 °C @ Press: 0.2-0.5 Torr

Flash Point：

243.5±28.7 °C

Refractive Index：

1.655

Toxicity：

LDLo oral in man: 107mg/kg

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

safety instructions：

Marks：

Xi,N

Precautionary statement(s)：

P273-P501

Hazard Statements：

H410

GHS Classification：

|Warning|H400 (97.56%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

10-(3-dimethylamino-2-methylpropyl)phenothiazine-2-carbonitrile

2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine Use and Manufacturing

Uses

Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:323.5
XLogP3:4.4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:323.14561886
Monoisotopic Mass:323.14561886
Topological Polar Surface Area:55.6
Heavy Atom Count:23
Complexity:443
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Hot Searches: 3-methylcyclohexene; cefepime; nitrohydrochloric acid; borane; ethylamine; triphenylmethanol

Guide of 2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties

2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazine

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