4-Chloro-6-methylpyrimidine

To a solution of 4, 6-dichloropyrimidine (1.0 g, 6.71 mmol) in tetrahydrofuran (30 mL) was added l-methyl-2-pyrrolidinone (3.2 mL, 6.71 mmol), iron(III) acetylacetonate (0.119 g, 0.336 mmol) and methylmagnesium bromide (2.237 mL, 6.71 mmol). The reaction mixture was stirred at RT for 3 h, then it was quenched with water and extracted with ethyl acetate (100 mL). The organic layer was separated out and concentrated under reduced pressure. The residue was purified by silica gel chromatography (20percent ethyl acetate-hexane) to afford 4-chloro-6- methylpyrimidine (0.6 g, 3.08 mmol, 46percent yield) as a colorless gummy liquid. LCMS (ESI) m/e 129.0 [(M+H)

Molecular Weight:128.56
XLogP3:1.5
Hydrogen Bond Acceptor Count:2
Exact Mass:128.0141259
Monoisotopic Mass:128.0141259
Topological Polar Surface Area:25.8
Heavy Atom Count:8
Complexity:76.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes