2-Linoleoylglycerol

Colourless Oil

Solid

2-linoleoylglycerol is a 2-monoglyceride where linoleoyl forms the 2-acyl group. It derives from a linoleic acid.

A fatty acid 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. The congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group is 2-linoleoyl glycerol (2-LG), and this compound also appears in vivo in conjunction with 2-AG. Although the intrinsic activity of 2-LG is low, it potentiates the activity of other endocannabinoids, including 2-AG. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release.

Molecular Weight:354.5
XLogP3:5.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:18
Exact Mass:354.27700969
Monoisotopic Mass:354.27700969
Topological Polar Surface Area:66.8
Heavy Atom Count:25
Complexity:346
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes