3-Pyridineacetamide

The starting material was prepared as follows : To a stirred slurry of the ethyl 3-pyridylacetate (5.00 g ; 30.2 mmol) was added concentrated NH40H (50 ml), the resulting suspension was stirred at room temperature overnight. The solution was evaporated to dryness to afford a solid, which was washed with MeCN-ether (100 ml, 3:1) and dried to a constant weight in a vacuum oven to give 20 as a white solid. Yield: 76 percent Amides within the scope of substituted benzoylalkylamino are ... 4-methyl-alpha-pyridylamide, 4-methyl-beta-pyridylamide, 4-chloro-alpha-pyridylamide, and 4-chloro-beta-pyridylamide. alpha-pyridylmethylamide, beta-pyridylmethylamide, gamma-pyridylmethylamide, alpha-pyridylethylamide, beta-pyridylethylamide, gamma-pyridylethylamide, alpha-pyridylpropylamide, beta-pyridylpropylamide, gamma-pyridylpropylamide, alpha-pyridylbutylamide, beta-pyridylbutylamide, and gamma-pyridylbutylamide. ...General procedure: Following the amide intermediate Preparation Example A. The reaction vessel is closed (when the amide intermediate has a boiling point at normal pressure equal to or lower than the reaction temperature TB described below) or the reaction vessel is kept open (when the amide intermediate has a boiling point higher than the normal pressure When the reaction temperature is TB), stirring is continued (600 r/min), the reaction temperature is changed to TB, and after the reaction temperature TB is maintained for TD hours, the reaction is substantially completed. Then, the reaction vessel was sealed and connected to a vacuum pump so that the degree of vacuum in the reaction vessel reached 20-50 mbar (according to the type of nitrile product) and the distillate was used as the nitrile product. The yield of the nitrile product was calculated and sampled for nuclear magnetic resonance and elemental analysis to characterize the nitrile product obtained. Specific reaction conditions and characterization results are shown in Tables A-7, A-8, A-9, A-10, A-11 and A-12 below. These characterization results show that the nitrile product obtained has an extremely high purity (above 99%).In these nitrile product preparation examples, 10 g of phosphorus pentaoxide is preferably added to the reaction vessel as a catalyst at one stage, optionally at the beginning of the reaction.

Molecular Weight:136.15
XLogP3:-0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:136.063662883
Monoisotopic Mass:136.063662883
Topological Polar Surface Area:56
Heavy Atom Count:10
Complexity:125
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes