Chloroprocaine hydrochloride
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Chloroprocaine hydrochloride
structure -
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CAS No:
3858-89-7
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Formula:
C13H19ClN2O2.ClH
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Chemical Name:
Chloroprocaine hydrochloride
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Synonyms:
Benzoic acid,4-amino-2-chloro-,2-(diethylamino)ethyl ester,hydrochloride (1:1);Benzoic acid,4-amino-2-chloro-,2-(diethylamino)ethyl ester,monohydrochloride;2-Chloro-4-aminobenzoic acid diethylaminoethyl ester hydrochloride;Chloroprocaine hydrochloride;2-Chloroprocaine hydrochloride;2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate hydrochloride;Nesacaine hydrochloride;Chlorprocaine hydrochloride;Nesacaine
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CAS No:
Description
crystalline solid
Chloroprocaine hydrochloride is the monohydrochloride salt of chloroprocaine. Used as a local anaesthetic, particularly for oral surgery, it has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. It has a role as a local anaesthetic, a peripheral nervous system drug and a central nervous system depressant. It contains a chloroprocaine.|Chloroprocaine Hydrochloride is a synthetic, aminoester, local, anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma.
Chloroprocaine hydrochloride Basic Attributes
307.2161
306.090179
223-371-2
LT7Z1YW11H
DTXSID6048595
C47444
2922492050
Safety Information
NONH for all modes of transport
Stable. Incompatible with strong oxidizing agents.
P264, P270, P301+P310, P321, P330, P405, P501
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Intrathecal anaesthesia|Ocular surface anaesthesia|Epidural anaesthesia|Peripheral nerve block (local anaesthesia by perineural injection)
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)
2-chloroprocaine
Chloroprocaine hydrochloride Use and Manufacturing
Anesthetic (local).
Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:307.21
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:306.0901833
Monoisotopic Mass:306.0901833
Topological Polar Surface Area:55.6
Heavy Atom Count:19
Complexity:259
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Local anesthetics
Registered Holders
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EDMOND PHARMA SRL
Active
United States
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SIEGFRIED EVIONNAZ SA
Active
France
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Chengdu Sino-Strong Pharmaceutical Co., Ltd.
Active
China
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