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Home > Encyclopedia > Chloroprocaine hydrochloride

Chloroprocaine hydrochloride

pharmaceutical raw materials
Chloroprocaine hydrochloride structure

Chloroprocaine hydrochloride 

structure
  • CAS No:

    3858-89-7

  • Formula:

    C13H19ClN2O2.ClH

  • Chemical Name:

    Chloroprocaine hydrochloride

  • Synonyms:

    Benzoic acid,4-amino-2-chloro-,2-(diethylamino)ethyl ester,hydrochloride (1:1);Benzoic acid,4-amino-2-chloro-,2-(diethylamino)ethyl ester,monohydrochloride;2-Chloro-4-aminobenzoic acid diethylaminoethyl ester hydrochloride;Chloroprocaine hydrochloride;2-Chloroprocaine hydrochloride;2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate hydrochloride;Nesacaine hydrochloride;Chlorprocaine hydrochloride;Nesacaine

  • Categories:

    Active Pharmaceutical Ingredients  >  Anesthetic Agents

Description

crystalline solid


Chloroprocaine hydrochloride is the monohydrochloride salt of chloroprocaine. Used as a local anaesthetic, particularly for oral surgery, it has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. It has a role as a local anaesthetic, a peripheral nervous system drug and a central nervous system depressant. It contains a chloroprocaine.|Chloroprocaine Hydrochloride is a synthetic, aminoester, local, anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma.

Chloroprocaine hydrochloride Basic Attributes

307.2161

306.090179

223-371-2

LT7Z1YW11H

DTXSID6048595

C47444

2922492050

Characteristics

41.57000

3.62590

177 °C

402.6ºC at 760 mmHg

Safety Information

NONH for all modes of transport

Stable. Incompatible with strong oxidizing agents.

P264, P270, P301+P310, P321, P330, P405, P501

H301

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

Intrathecal anaesthesia|Ocular surface anaesthesia|Epidural anaesthesia|Peripheral nerve block (local anaesthesia by perineural injection)

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

2-chloroprocaine

Chloroprocaine hydrochloride Use and Manufacturing

Uses

Anesthetic (local).

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:307.21
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:306.0901833
Monoisotopic Mass:306.0901833
Topological Polar Surface Area:55.6
Heavy Atom Count:19
Complexity:259
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Local anesthetics

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

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