Perfluorooctyl bromide
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Perfluorooctyl bromide
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CAS No:
423-55-2
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Formula:
C8BrF17
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Chemical Name:
Perfluorooctyl bromide
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Synonyms:
Octane,1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-;Octane,1-bromoheptadecafluoro-;1-Bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane;Perfluoroctyl bromide;1-Bromoperfluorooctane;Perfluorooctyl bromide;Imagent;PFOB;Perflubron;Imagent BP;Oxygent;Oxygent CA;n-Perfluorooctyl bromide;1-Bromoheptadecafluorooctane;Oxygent HT;Foralkyl Br 8;AF 0104;AFO 150;FO 6167;121762-73-0;159074-78-9;1201928-38-2
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CAS No:
Description
Perflubron(1-Bromoheptadecafluorooctane;Heptadecafluorooctyl bromide; Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron (1-Bromoheptadecafluorooctane;Heptadecafluorooctyl bromide; Perfluorooctyl bromide) can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics[1][2].
Perflubron is a haloalkane that is perfluorooctane in which a fluorine attached to one of the terminal carbons has been replaced by a bromine. It has a role as a radioopaque medium and a blood substitute. It is a perfluorinated compound, an organobromine compound and a haloalkane. It derives from a hydride of an octane.|Perflubron (Oxygent) is being developed as an intravascular oxygen carrier designed to augment oxygen delivery in surgical patients.|Perflubron is a synthetic radiopaque liquid form of perfluorooctyl bromide. Used as a contrast agent for magnetic resonance imaging (MRI), perflubron is also used as a liquid ventilation agent to improve pulmonary gas exchange and lung compliance and may be used in surgery to reduce or eliminate the need for donor blood. Ventilation with perfluorocarbon fluid improves lung function in conditions involving surfactant deficiency and dysfunction, including respiratory distress syndrome and adult respiratory distress syndrome. (NCI04)
Perfluorooctyl bromide Basic Attributes
498.96
498.96
2016022
207-028-4
Q1D0Q7R4D9
DTXSID5046560
C1422
V - Various
2903799090
Characteristics
0
6.34820
Colorless to tan Viscous Solution
1.93 g/cm3
<25 °C
141 °C
141-143°C
n20/D 1.305(lit.)
Not miscible or difficult to mix in water.
6.54mmHg at 25°C
LD50 i.v. in female rats: 41 g/kg (Burgan)
Safety Information
III
6.1(b)
2810
3
36/37/38
26-37/39
RG8700000
Xi
Irritant
P305 + P351 + P338
H315-H319-H335
Drug Information
Investigated for use/treatment in cardiac surgery, hemorrhage, and ileus.
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells. (See all compounds classified as Radiation-Sensitizing Agents.)|Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)|Agents that increase energy expenditure and weight loss by neural and metabolic regulation. (See all compounds classified as Anti-Obesity Agents.)
Perflubron emulsion (Oxygent) maintains hemodynamic stability during major surgery, thereby potentially reducing or avoiding intraoperative transfusions of donor blood in major surgery.Perflubron emulsion has ability to enable patients to be physiologically stable and safe at lower intraoperative Hb levels.
AF0144
Perfluorooctyl bromide Use and Manufacturing
Oxygen carrier in emulsions used as blood substitutes.1
Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|PFAS (per- and polyfluoroalkyl substances) -> OECD Category
Computed Properties
Molecular Weight:498.96
XLogP3:6.9
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:6
Exact Mass:497.89119
Monoisotopic Mass:497.89119
Heavy Atom Count:26
Complexity:527
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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