OBSH

358.393

358.39

201-286-1

70377EJ95Z

5318

3226

DTXSID7026499

Fine white crystalline powder

170.37000

0.70

Diphenyloxide-4,4'-disulfonyl hydrazide appears as a colorless, crystalline solid with a geranium-like odor. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. Moderately toxic by ingestion, inhalation and skin absorption. Readily ignited by sparks or flames and burns intensely and persistently.

1.52 g/cm³

150-160 °C (decomp)

590.0±60.0 °C at 760 mmHg

310.6±32.9 °C

1.645

Insoluble in water.

6.91x10-11 mmHg (est)

1.52

mma-sat 800 mg/plate NEZAAQ 33,474,78

Odorless

Henry's law constant = 1.26X10-17 atm-cu m/mol at 25 °C (est)

Insoluble in water.

Azo, Diazo, Azido, Hydrazine, and Azide Compounds

DIPHENYLOXIDE-4,4'-DISULFOHYDRAZIDE is an azide. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

3226

3

R11;R44

S26-S37/39

DB7321000

Xi

P210, P220, P234, P260, P264, P270, P273, P280, P305+P351+P338, P309+P311, P314, P337+P313, P370+P378, P391, P403+P235, P405, P411, P420, P501

H242

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]: Self-decomposition, self-polymerization, or self-ignition may be triggered by heat, chemical reaction, friction or impact. May be ignited by heat, sparks or flames. Some may decompose explosively when heated or involved in a fire. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. May burn violently. Decomposition or polymerization may be self-accelerating and produce large amounts of gases. Vapors or dust may form explosive mixtures with air. (ERG, 2016)|Flammable - 3rd degree, Reactive - 2nd degree

|Warning|H228 (47.37%): Flammable solid [Danger Flammable solids]|P201, P202, P210, P220, P234, P240, P241, P260, P261, P264, P270, P271, P272, P273, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P370+P378, P391, P403+P233, P403+P235, P405, P411, P420, and P501|Aggregated GHS information provided by 336 companies from 31 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H242: Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]|P210, P220, P234, P260, P264, P270, P273, P280, P305+P351+P338, P309+P311, P314, P337+P313, P370+P378, P391, P403+P235, P405, P411, P420, and P501|Danger|P210, P220, P234, P260, P264, P270, P280, P305+P351+P338, P309+P311, P314, P337+P313, P370+P378, P403+P235, P405, P411, P420, and P501|H303: May be harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P305+P351+P338, P309+P311, P312, P337+P313, P405, and P501

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. LARGE SPILL: Consider initial evacuation for at least 250 meters (800 feet) in all directions. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch or walk through spilled material. Stop leak if you can do it without risk. SMALL SPILL: Pick up with inert, damp, non-combustible material using clean, non-sparking tools and place into loosely covered plastic containers for later disposal. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2016)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection. (ERG, 2016)|Protective gloves. Safety spectacles.|Personal protection: P1 filter respirator for inert particles.

Not combustible.

In case of fire in the surroundings: use appropriate extinguishing media.

Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place.

LD50 Rat oral > 5,200 mg/kg bw|LD50 Rat oral 2,300 mg/kg bw|LD50 Mouse oral > 5,000 mg/kg bw

p,p'-Oxybis(benzenesulfonyl hydrazide)'s production and use as a blowing agent for sponge rubber and expanded plastics(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 880(SRC), determined from a structure estimation method(2), indicates that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to have low mobility in soil(SRC). Volatilization of p,p'-oxybis(benzenesulfonyl hydrazide) from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.26X10-17 atm-cu m/mole(SRC), using a fragment constant estimation method(3). p,p'-Oxybis(benzenesulfonyl hydrazide) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.91X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). A 2% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 880(SRC), determined from a structure estimation method(2), indicates that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.26X10-17 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), BCF values of less than 3.0(6), suggest bioconcentration in aquatic organisms is low(SRC). A 2% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is not an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), p,p'-oxybis(benzenesulfonyl hydrazide), which has an estimated vapor pressure of 6.91X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase p,p'-oxybis(benzenesulfonyl hydrazide) may be removed from the air by wet or dry deposition(SRC). p,p'-Oxybis(benzenesulfonyl hydrazide) does not contain chromophores that absorb at wavelengths >290 nm(3), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

p,p'-Oxybis(benzenesulfonyl hydrazide) is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). p,p'-Oxybis(benzenesulfonyl hydrazide) does not contain chromophores that absorb at wavelengths >290 nm(1), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

BCF values of <0.3 and <3.0 were calculated in carp (Cyprinus carpio) for p,p'-oxybis(benzenesulfonyl hydrazide), exposed over a 6 week test period to 1 mg/L and 0.1 mg/L, respectively(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of p,p'-oxybis(benzenesulfonyl hydrazide) can be estimated to be 880(SRC). According to a classification scheme(2), this estimated Koc value suggests that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to have low mobility in soil.

The Henry's Law constant for p,p'-oxybis(benzenesulfonyl hydrazide) is estimated as 1.26X10-17 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that p,p'-oxybis(benzenesulfonyl hydrazide) is expected to be essentially nonvolatile from water surfaces(2). p,p'-Oxybis(benzenesulfonyl hydrazide) is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.91X10-11 mm Hg(SRC), determined from a fragment constant method(3).

According to the 2006 TSCA Inventory Update Report, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of p,p'-oxybis(benzenesulfonyl hydrazide) is 1,000 or greater; the data may be greatly underestimated(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 5,939 workers (282 of these were female) were potentially exposed to p,p'-oxybis(benzenesulfonyl hydrazide) in the US(1). Occupational exposure to p,p'-oxybis(benzenesulfonyl hydrazide) may occur through inhalation of dust and dermal contact with this compound at workplaces where p,p'-oxybis(benzenesulfonyl hydrazide) is produced or used. Exposure to the general population is limited(SRC).

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]: Inhalation or contact with vapors, substance or decomposition products may cause severe injury or death. May produce irritating, toxic and/or corrosive gases. Runoff from fire control may cause pollution. (ERG, 2016)

Excerpt from ERG Guide 149 [Substances (Self-Reactive)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Keep victim calm and warm. (ERG, 2016)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic acids and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Activated charcoal is not effective ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic acids and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic acids and related compounds/

/GENOTOXICITY/ The test substance was evaluated for its ability to induce chromosomal aberrations in primary human lymphocyte cells in the presence and absence of a rat liver homogenate metabolic activation system. The test article was tested at the following concentrations: Neat and 1:2, 1:4, 1:8, 1:16, 1:32, and 1:64 dilutions of the neat extract. The concentrations chosen to be scored for the activated assay were neat and 1:2 and 1:4 dilutions of the test extract. The results indicate that the test substance did not cause a statistically significant increase in the number of chromosome aberrations (p < 0.05). This was observed for both activated and non-activated system. In addition, there was no detectable dose response in the number of aberrations of both activated and non-activated systems, verifying the validy of the test system. In conclusion, the test substance did not induce aberrations in primary cultured human lymphocytes and is considered non-clastogenic.

Plastics product manufacturing|Benzenesulfonic acid, 4,4'-oxybis-, 1,1'-dihydrazide: ACTIVE

Fire Hazards -> Flammable - 3rd degree, Reactive - 2nd degree