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Ruscogenin

Ruscogenin structure

CAS No:
472-11-7
Formula:
C27H42O4
Chemical Name:
Ruscogenin
Synonyms:
Spirost-5-ene-1,3-diol,(1β,3β,25R)-;Spirost-5-ene-1β,3β-diol,(25R)-;Ruscogenin;Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran],spirost-5-ene-1,3-diol deriv.;(1β,3β,25R)-Spirost-5-ene-1,3-diol;25D-Spirost-5-ene-1β,3β-diol;25R-Ruscogenin;881025-73-6
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities[1][2].

Ruscogenin is a triterpenoid.

Ruscogenin Basic Attributes

Molecular Weight：

430.62

Exact Mass：

430.62

EC Number：

207-447-2

UNII：

BXI92R2VUJ

HScode：

29389090

Characteristics

PSA：

58.9

XLogP3：

4.29

Density：

1.2±0.1 g/cm3

Melting Point：

198-202 °C

Boiling Point：

563.1±50.0 °C at 760 mmHg

Flash Point：

294.4±30.1 °C

Refractive Index：

1.577

Vapor Pressure：

5.03E-15mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

safety instructions：

24/25

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

ruscogenin

Ruscogenin Use and Manufacturing

Uses

A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.

Use Classification：

Lipids -> Sterol Lipids [ST] -> Sterols [ST01] -> Spirostanols and derivatives [ST0108]|Cosmetics -> Skin conditioning

Computed Properties

Molecular Weight:430.6
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Exact Mass:430.30830982
Monoisotopic Mass:430.30830982
Topological Polar Surface Area:58.9
Heavy Atom Count:31
Complexity:779
Defined Atom Stereocenter Count:12
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Ruscogenin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Ruscogenin

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