19-Norprogesterone
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19-Norprogesterone
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CAS No:
472-54-8
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Formula:
C20H28O2
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Chemical Name:
19-Norprogesterone
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Synonyms:
19-Norpregn-4-ene-3,20-dione;19-Norprogesterone;Norprogesterone;U 25879;NSC 22021;19-Nor-P4;12002-13-0
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CAS No:
Description
19-Norprogesterone is a corticosteroid hormone.|19-Norprogesterone is a steroid progestin derivative with antigonadotropic activity. 19-nor-Progesterone decreases luteinizing hormone (LH) and follicle stimulatory hormone (FSH) secretion, which are effects likely mediated through the binding of this agent to the progesterone receptor. The antigonadotropic activity of this hormone results in reinforcement of its antiestrogenic activity, allowing treatment of the clinical hyper-estrogenic symptoms of peri-menopause without negative metabolic or hemostatic effects. 19-nor-Progesterone, in addition to its inhibitory effect on ovulation, induces changes in the endometrium, rendering it resistant to implantation, and in the cervical mucus, rendering it hostile to spermatozoa migration. This agent is also a potent mineralocorticoid. (NCI04)
Characteristics
34.1
4.33340
1.1g/cm3
144-145 °C
447.4ºC at 760mmHg
166.8ºC
1.545
36.1mg/L(37 ºC)
3.38E-08mmHg at 25°C
TDLo imp-mus: 234 mg/kg/56W-C:ETA NATUAS212,686,66
Computed Properties
Molecular Weight:300.4
XLogP3:3.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:300.208930132
Monoisotopic Mass:300.208930132
Topological Polar Surface Area:34.1
Heavy Atom Count:22
Complexity:546
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes