Methyl 2-chloro-2-propenoate

120.53

120.53

201-298-7

47PG4L077J

32608

2929|2810

DTXSID4025585

COLORLESS LIQUID

29161995

26.30000

0.91190

Clear colorless to slightly brown Liquid

1.189 g/cm³ @ Temp: 20 °C

52 °C @ Press: 51 Torr

33 °C

1.426

> 10% in ether

0-6°C

Highly flammable. Insoluble in water.

Halogenated Organic Compounds

Highly Flammable

METHYL 2-CHLOROACRYLATE is sensitive to prolonged exposure to light, moisture and heat. This chemical is incompatible with oxidizers and polymerizers. (NTP, 1992)

II

6.1(a)

2927

34-26-24/25-10

45-38-36/37/39-26-16

T+

P210, P233, P240, P241, P242, P243, P260, P264, P270, P271, P280, P284, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, P501

H226

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

|Danger|H226 (80%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P270, P271, P280, P284, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 10 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fight fire from maximum distance. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. (Non-Specific -- Poisonous Liquid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk. (EPA, 1998)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

(Non-Specific -- Poisonous Liquid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|SUITABLE PROTECTIVE CLOTHING & SELF-CONTAINED RESP PROTECTIVE APPARATUS SHOULD BE AVAILABLE FOR USE OF THOSE WHO MAY HAVE TO RESCUE PERSONS OVERCOME BY FUMES. /ACRYLIC ACID & DERIVATIVES/

IT IS NECESSARY TO TAKE STRONG PREVENTIVE MEASURES IN FACTORY, BOTH WITH REGARD TO SKIN & RESPIRATORY TRACT.|... Hazard is the generation of considerable exothermic heat in some of the reactions, so that high pressures & temp may develop. This danger... should be borne in mind when designing plant. Awareness of the dangers and of good engineering design are essential to safety. Employees should be instructed about the necessity of cleansing the skin if it is contaminated by materials which are irritants or skin-absorbed. With careful design, however, and complete enclosure of those processes where toxic chemicals or intermediates occur, dangerous exposures can be avoided. /Acrylic acid & derivatives/|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

... AT VERY LOW CONCN (5-10 PPM) THE VAPORS OF THIS MONOMER HAVE VERY IRRITATING ACTION ON EYES.|A severe skin irritant.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Methyl 2-chloroacrylate is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 lbs.

LC50 Rat ihl 500 mg/cu m/2 hr|LC50 Mouse ihl 500 mg/cu m/2 hr|LC50 Cat ihl 500 mg/cu m/2 hr|LC50 Rabbit ihl 500 mg/cu m/2 hr|LC50 Guinea Pig ihl 500 mg/cu m/2 hr

It is a skin, eye, and lung irritant. The least trace on skin raises large blisters. It is also a respiratory poison; breathing the vapors can cause pulmonary edema. (EPA, 1998)

Warning: Methyl 2-chloroacrylate is a strong eye, skin, and lung irritant and a respiratory poison. The least trace on skin raises large blisters. Caution is advised. Signs and Symptoms of Methyl 2-Chloroacrylate Exposure: Signs and symptoms of acute exposure to methyl 2-chloroacrylate may include irritation, conjunctivitis, burns, and blisters of the skin. Respiratory exposure may include strong pulmonary irritation, dyspnea, pulmonary edema, headache, lethargy, convulsions. Gastrointestinal symptoms may include nausea. Emergency Life-Support Procedures: Acute exposure to methyl 2-chloroacrylate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to methyl 2-chloroacrylate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to methyl 2-chloroacrylate. 2. Evaluate vital signs including pulse and respiratory rate and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove and isolate contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 2. DO NOT induce vomiting. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 5. Transport to a health care facility. (EPA, 1998)

IT IS ... A RESPIRATORY POISON, & BREATHING ITS VAPORS CAN CAUSE PULMONARY EDEMA. EVEN AT VERY LOW CONCN (5-10 PPM) THE VAPORS OF THIS MONOMER HAVE VERY IRRITATING ACTION ON EYES.|REPLACEMENT OF A CH3 GROUP ... BY A CHLORINE ATOM CONSIDERABLY INCREASES THE IRRITANT PROPERTIES.|Methyl-alpha-chloroacrylate is a strong vesicant; a trace on the skin causes large blisters.