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Colchiceine

Colchiceine structure

CAS No:
477-27-0
Formula:
C21H23NO6
Chemical Name:
Colchiceine
Synonyms:
Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-;Colchiceine;Acetamide,N-(5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-;Benzo[a]heptalene,acetamide deriv.;N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide;O10-Demethylcolchicine;NSC 33411;10-O-Demethylcolchicine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Off- White to Pale Yellow Solid

Colchiceine is one of several metabolites of the anti-gout medication [colchicine].

Colchiceine Basic Attributes

Molecular Weight：

385.416

Exact Mass：

385.41

EC Number：

207-512-5

NSC Number：

371715

HScode：

2924299090

Characteristics

PSA：

94.1

XLogP3：

2.95950

Density：

1.31g/cm3

Melting Point：

178.5 °C

Boiling Point：

731.5ºC at 760mmHg

Flash Point：

396.2ºC

Refractive Index：

1.61

Toxicity：

LD50 intraperitoneal in mouse: 84mg/kg

Safety Information

Precautionary statement(s)：

P260, P264, P270, P271, P284, P301+P310, P304+P340, P310, P320, P321, P330, P403+P233, P405, P501

Hazard Statements：

H300

Drug Information

Metabolism/Metabolites：

Colchiceine is a known human metabolite of (R)-colchicine.

Colchiceine Use and Manufacturing

A metabolite of Colchicine

Computed Properties

Molecular Weight:385.4
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:385.15253745
Monoisotopic Mass:385.15253745
Topological Polar Surface Area:94.1
Heavy Atom Count:28
Complexity:724
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Colchiceine

Unit Price: $12316-13000 /G FOB

CAS No.: 477-27-0

Grade: Industrial Grade

Content: 98%

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