4-Thiazolidinecarboxylic acid
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4-Thiazolidinecarboxylic acid
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CAS No:
444-27-9
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Formula:
C4H7NO2S
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Chemical Name:
4-Thiazolidinecarboxylic acid
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Synonyms:
4-Thiazolidinecarboxylic acid;T 4CA;4-Carboxythiazolidine;Thiazolidinecarboxylic acid;Timonacic;Hepalidine;Heparegene;γ-Thiaproline;Thioproline;Thiaproline;Heparegen;DL-4-Thiazolidinecarboxylic acid;(±)-4-Thiazolidinecarboxylic acid;DL-Thiaproline;Norgamen;ATC;Detoxepa;Tiazolidin;NSC 25855;Norgamem;1,3-Thiazolidine-4-carboxylic acid;1,3-Thiazolane-4-carboxylic acid;1,3-Thiazolidin-3-ium-4-carboxylate;19291-02-2;60731-25-1;2756-91-4
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CAS No:
Description
Timonacic is used as an adjuvant in the treatment of acute and hepatic disorders. It has also been used for the treatment of some cases of cancer, through the induction of the reverse transformation.
Thioproline is a sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom. It has a role as a hepatoprotective agent, an antioxidant and an antidote. It is a sulfur-containing amino acid, a thiazolidinemonocarboxylic acid and a non-proteinogenic alpha-amino acid. It is a tautomer of a thioproline zwitterion.|Timonacic has been used in trials studying the treatment of HIV Infections.
4-Thiazolidinecarboxylic acid Basic Attributes
133.169
133.17
256-240-3
758453|25855
DTXSID9023675
2934999090
Characteristics
74.63000
-0.39
1.4±0.1 g/cm3
196.5 °C
350.3±37.0 °C at 760 mmHg
165.7±26.5 °C
1.566
29.3g/L(21 ºC)
Safety Information
III
6.1(b)
UN 2811
P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, P501
H302
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)
gamma-thiaproline
4-Thiazolidinecarboxylic acid Use and Manufacturing
hepatoprotectant
4-Thiazolidinecarboxylic acid: INACTIVE
Computed Properties
Molecular Weight:133.17
XLogP3:-2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:133.01974964
Monoisotopic Mass:133.01974964
Topological Polar Surface Area:74.6
Heavy Atom Count:8
Complexity:106
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-Thiazolidinecarboxylic acid
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