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    Home > Natural Products > Anthraquinone > DAMNACANTHAL
    DAMNACANTHAL structure

    DAMNACANTHAL

    • CAS No:

      477-84-9

    • Formula:

      C16H10O5

    • Synonyms:

      DAMNACANTAL;DAMNACANTHAL;3-HYDROXY-1-METHOXYANTHRAQUINONE-2-ALDEHYDE;1-Methoxy-2-formyl-3-hydroxy-9,10-anthraquinone;3-Hydroxy-1-Methoxy-2-anthraquinonecarboxaldehyde;1-Methoxy-3-hydroxy-9,10-dioxoanthracene-2-carbaldehyde;3-hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde;3-hydroxy-1-methoxy-9,10-dioxo-anthracene-2-carbaldehyde;3-hydroxy-9,10-diketo-1-methoxy-anthracene-2-carbaldehyde;9,10-Dihydro-3-hydroxy-1-Methoxy-9,10-dioxo-2-anthraldehyde

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    Description

    Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 lck autophosphorylation and phosphorylation of exogenous substrates with IC50s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity agains

    Basic Attributes

    • 477-84-9

    • C16H10O5

    • 282.25

    • 282.052826

    • 80.7 A^2

    • 3.74

    • IPDMWUNUULAXLU-UHFFFAOYSA-N

    • 5

    • 1

    • 2

    Characteristics

    • 1.5±0.1 g/cm3

    • 218~219℃

    • 531.9±50.0 °C at 760 mmHg

    • 204.9±23.6 °C

    • 1.692

    Safety Information

    Product Usage

    Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity. Damnacanthal is used in the treatment of inflammatory-related diseases.

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