 Home > Encyclopedia > 2-Fluorobenzyl alcohol

2-Fluorobenzyl alcohol

2-Fluorobenzyl alcohol structure

CAS No:
446-51-5
Formula:
C7H7FO
Chemical Name:
2-Fluorobenzyl alcohol
Synonyms:
Benzenemethanol,2-fluoro-;Benzyl alcohol,o-fluoro-;2-Fluorobenzenemethanol;2-Fluorobenzyl alcohol;o-Fluorobenzyl alcohol;(2-Fluorophenyl)methanol;NSC 158274;185532-96-1
Categories:
Organic Chemistry > Organic Fluorine Compound

Request for Quotation

Description

clear colorless to slightly yellow liquid

2-Fluorobenzyl alcohol Basic Attributes

Molecular Weight：

126.13

Exact Mass：

126.13

BRN：

2079486

EC Number：

207-170-7

NSC Number：

158274

DSSTox ID：

DTXSID10196241

HScode：

29062900

Characteristics

PSA：

20.2

XLogP3：

1.3

Appearance：

Clear colorless to slightly yellow Liquid

Density：

1.2±0.1 g/cm3

Melting Point：

91-94 °C

Boiling Point：

82 °C @ Press: 10 Torr

Flash Point：

195 °F

Refractive Index：

1.521

Storage Conditions：

Store below +30°C.

Vapor Pressure：

1.16mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

wgk germany：

hazard class code：

14-34-36/37

safety instructions：

23-24/25-45-36/37/39-27-26

Marks：

Xi,C

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

2-Fluorobenzyl alcohol Use and Manufacturing

Methods of Manufacturing

Preparation of (1, 2, 3, 10-tetramethoxy-9-oxo-5, 6, 7, 9-tetrahydro-benzo[a]heptalen-7-yl)-carbamic acid 2-fluoro benzyl ester (Compound 5) 106 mg (0.84 mmol) of To a solution of XIIf (0.2 g, 1.5 mmol) and 26 2-hydroxyisoindoline-1, 3-dione (0.435 g, 2.3 mmol) in dry 32 THF (2 mL) at room temperature was added 46 triphenyl phosphine (0.498 g, 1.9 mmol) and the system was stirred for 30 minutes. The reaction mixture was cooled to 0 C., 47 DEAD (0.330 g, 1.9 mmol) was added dropwise and the reaction mixture was stirred at room temperature for 16 h. The reaction mixture was quenched with cold 67 water (50 mL) and extracted with EtOAc (2×50 mL). The combined organic layers were washed with water (25 mL), brine (25 mL), then dried over sodium sulfate, and evaporated under vacuum to give crude product. The crude product was purified by column chromatography (0-10% 29 EtOAc in 93 pet ether) to provide 94 XIIIf (0.130 g, 30% yield) as a white solid. 1H NMR (500 MHz, DMSO-d6): delta 7.86 (m, 4H), 7.59-7.54 (m, 2H), 7.26-7.21 (m, 2H), 5.15 (s, 2H).General procedure: To a solution of alcohol (1mmol) in freshly distilled THF (5ml) was added triphenylphosphine (1.1mmol) and N-hydroxylphthalimide (1.1mmol). After the solution was cooled to 0C diisopropylazodicarboxylate (1.1mmol) was added dropwise. The solution was allowed to warm to room temperature over 3h. Reaction progress was monitored by TLC (1:1 heptanes:ethyl acetate). Hydrazine monohydrate (1.1mmol) was then added and the solution was allowed to stir for 30min. The resulting reaction mixture was filtered to remove the white precipitate. The filtrate was concentrated and subjected to flash chromatography (1:1 heptanes/ethyl acetate). The resulting product was dissolved in ether and treated with HCl (2.0M solution in ether) to afford the HCl salt of the O-alkylhydroxylamine. Contaminating diisopropyl hydrazinodicarboxylate could be washed away from the HCl salt with dichloromethane

Uses

Intermediate for medicine, pesticide, liquid crystal material.

Computed Properties

Molecular Weight:126.13
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:126.048093005
Monoisotopic Mass:126.048093005
Topological Polar Surface Area:20.2
Heavy Atom Count:9
Complexity:85
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Fluorobenzyl alcohol

QINGDAO EAST CHEMSOURCES TRADE CO.,LTD Contact Supplier

CN
8 YRS

Business licensed

Trader Supplier of Food additives,Pharmaceutical raw materials,Chemicals,Comestic raw materials

99%2-Fluorobenzyl alcohol

CAS No.: 446-51-5

Grade: Industrial Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2-Fluorobenzyl alcohol

CAS No.: 446-51-5

Content: 99.00%

Inquiry
Honour Enterprise Company Limited Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Semaglutide,Tirzepatide,API,Enzyme

More than 15 years GMP Factory Suppy 99.5% 2-Fluorobenzyl alcohol Medical Grade CAS446-51-5

CAS No.: 446-51-5

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry
H2-Chem Co Ltd Contact Supplier

CN
2 YRS

Business licensed Certified factory

Manufactory Supplier of AEEA-AEEA,Fmoc-AEEA,Fmoc-Lys(Alloc)-OH

2-Fluorobenzyl alcohol

CAS No.: 446-51-5

Grade: Industrial Grade

Content: 90%

Inquiry