Solasodine

413.64

413.64

204-774-2

179187|178260

HEXAGONAL PLATES FROM METHANOL OR BY SUBLIMATION IN HIGH VACUUM

41.49000

5.78

white to beige

1.0159 (rough estimate)

200-202 °C

532.75°C (rough estimate)

279.1±30.1 °C

1.6400 (estimate)

DMSO: soluble0.5mg/mL, clear (warmed)

2-8°C

8.21E-14mmHg at 25°C

D25 -98° (c = 0.14 in methanol); D -113° (CHCl3)

PKB: 6.3

ALKALINE REACTION TO LITMUS IN ALCOHOLIC SOLN

NONH for all modes of transport

22-24/25

WF1300000

A REVIEW ON THE UTILIZATION OF SOLASODINE AS A POTENTIAL ECDYSONE ANTAGONIST.[CAMBIE RC, POTTER GJ; UTILIZATION OF SOLASODINE AS A POTENTIAL ECDYSONE ANTAGONIST; CHEM NZ 43 (3): 91-4 (1979)]|A REVIEW AND DISCUSSION CONCERNING THE SOURCES, CHEMISTRY, BIOCHEMISTRY, ISOLATION AND DETERMINATION OF SOLASODINE.[MANN JD; PRODUCTION OF SOLASODINE FOR THE PHARMACEUTICAL INDUSTRY; ADV AGRON 30 207-45 (1978)]

SOLASODINE WAS ISOLATED FROM THE DRIED ROOTS AND LEAVES OF SOLANUM SURATTENSE.|DEVELOPING BERRIES AND LEAVES OF SOLANUM SISYMBRIFOLIUM WERE SCREENED FOR SOLASODINE CONTENT. THE CONTENT INCR WITH THE AGE OF THE BERRIES REACHING ITS MAX VALUE (7.2% OF DRY WT) 45 DAYS AFTER ANTHESIS WHEN THE COLOR WAS SCARLET. IN LEAVES THE CONTENT VARIED FROM 6.4 TO 7.2%.|THE SOLASODINE CONTENT IN THE FRUITS OF SOLANUM MARGINATUM DURING 3 STAGES OF MATURITY WAS INVESTIGATED. THE GREEN FRUIT CONTAINED 2.3% AND THE DEEP YELLOW FRUITS CONTAINED 1.4%.

LABELED SOLASODINE WAS INJECTED INTO 2 NORMAL MEN AND INTO SYRIAN HAMSTERS. IN BOTH MEN, BLOOD (3)H WAS LARGELY ASSOCIATED WITH ERYTHROCYTES WHICH AFTER 8 DAYS STILL ACCOUNTED FOR 3.3% OF THE DOSE; PLASMA CONTAINED 1.6%, URINE 7% AND FECES 20% OF THE DOSE. EXCRETION OF (3)H BY HAMSTERS HAD DECLINED TO A VERY LOW LEVEL AFTER 8 DAYS WHEN 22-30% OF THE DOSE HAD BEEN EXCRETED. UNCHANGED SOLASODINE WAS STILL DETECTABLE IN LIVER 22 DAYS AFTER ADMIN.

solasodine

A RADIOIMMUNOASSAY FOR THE DIRECT QUANTITATION OF NANOGRAM AMT OF SOLASODINE IN PLANTS WAS STUDIED.|AN EXTRACT OF SOLANUM KHASIANUM FRUITS WAS FRACTIONATED WITH CHROMATOFUGE. THE FRACTION CONTAINING SOLASODINE WAS APPLIED TO A HIGH-PERFORMANCE LIQ CHROMATOGRAPHY COLUMN AND THE EFFLUENT WAS MONITORED BY UV SPECTROSCOPY.|SOLASODINE WAS DETERMINED BY GAS LIQUID CHROMATOGRAPHY FROM EXTRACTS OF SOLANUM ALATUM AND S ATRIPLICIFOLIUM.