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4-Fluoro-2-methylaniline

4-Fluoro-2-methylaniline structure

CAS No:
452-71-1
Formula:
C7H8FN
Chemical Name:
4-Fluoro-2-methylaniline
Synonyms:
Benzenamine,4-fluoro-2-methyl-;o-Toluidine,4-fluoro-;4-Fluoro-2-methylbenzenamine;2-Amino-5-fluorotoluene;4-Fluoro-2-methylaniline;6-Amino-3-fluorotoluene;2-Methyl-4-fluoroaniline;4-Fluoro-o-toluidine;NSC 88300;(4-Fluoro-2-methylphenyl)amine;2-Methyl-4-Fluorophenylamine;4-Fluoro-2-methyl-1-aminobenzene
Categories:
Specialty Chemicals

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Description

colorlesstolightyellowliqui

4-Fluoro-2-methylaniline Basic Attributes

Molecular Weight：

125.14

Exact Mass：

125.14

BRN：

1931798

EC Number：

207-208-2

NSC Number：

88300

DSSTox ID：

DTXSID6060008

HScode：

29214300

Characteristics

PSA：

XLogP3：

1.4

Appearance：

colorless to light yellow liquid

Density：

1.1263 g/cm³ @ Temp: 18 °C

Melting Point：

14.2 °C

Boiling Point：

97 °C @ Press: 20 Torr

Flash Point：

190 °F

Refractive Index：

1.542

Storage Conditions：

Room temperature.

Vapor Pressure：

0.231mmHg at 25°C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

2810

wgk germany：

hazard class code：

20/21/22-36/37/38-23/24/25

safety instructions：

26-36/37/39-45-36

RTECS Number：

CY0500000

Marks：

Xn,T,Xi

Hazard note：

Toxic/Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302 + H312 + H332-H315-H319-H335

4-Fluoro-2-methylaniline Use and Manufacturing

Methods of Manufacturing

To a solution of 4-fluoro-2-methyl-1-nitrobenzene (3b, 243 mL, 2.00 mmol) in MeOH (10 mL) was added 10percent Pd/C (21 mg, 0.020 mmol). The reaction mixturewas stirred and bubbled with H2at room temperature for 2 h. The solids were filtered off andwashed with DCM (25 mL). The filtrate and DCM washing werecombined and concentrated under reduced pressure. The residuewas purified by flash column chromatography (silica gel, P.E.ramping to PE:EtOAc 4:1) to give 4b as a pink oil (250 mg, 100percent).General procedure for deprotection of tert-butylsulfinyl group: N-(4-cyano-3-fluorophenyl)-2-methylpropane-2-sulfinamide (240 mg, 1.0 mmol) in 1, 4-dioxane (4 ml) was added 4.0M HCl in dioxane (4ml) and stirred at room temperature for 15 min. Reaction mixture was diluted with water, basified with saturated NaHCO

Uses

Is an intermediate in the synthesis of pesticides, medicines and dyes

Manufacturing Info：

Benzenamine, 4-fluoro-2-methyl-: INACTIVE

Computed Properties

Molecular Weight:125.14
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:125.064077422
Monoisotopic Mass:125.064077422
Topological Polar Surface Area:26
Heavy Atom Count:9
Complexity:94.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-Fluoro-2-methylaniline

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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4-Fluoro-2-methylaniline

CAS No.: 452-71-1

Content: 99.00%

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