1-Fluoro-2-iodo-4-methylbenzene
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1-Fluoro-2-iodo-4-methylbenzene
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CAS No:
452-82-4
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Formula:
C7H6FI
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Chemical Name:
1-Fluoro-2-iodo-4-methylbenzene
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Synonyms:
Benzene,1-fluoro-2-iodo-4-methyl-;Toluene,4-fluoro-3-iodo-;1-Fluoro-2-iodo-4-methylbenzene;NSC 29032;4-Fluoro-3-iodotoluene;3-Iodo-4-fluorotoluene
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CAS No:
Characteristics
0
3
colorless to light yellow liquid
1.8±0.1 g/cm3
122-125 °C30 mm Hg(lit.)
140 °F
1.581
0.256mmHg at 25°C
Safety Information
IRRITANT
UN 1992 3/PG 3
2
25-52/53
26-45
T,Xi
Irritant
P301 + P310
H226-H301
|Danger|H226 (97.44%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P310, P303+P361+P353, P321, P330, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-Fluoro-2-iodo-4-methylbenzene Use and Manufacturing
4-(Bromomethyl)-l-fluoro-2-iodobenzene Int-10 Step 1: 4-(Bromomethyl)-l-fluoro-2-iodobenzene Int-10 A mixture of General procedure: A sealed tube equipped with a magnetic stir bar was charged with the corresponding 1-bromo -2-fluoro (or chloro) benzene/ 1-fluoro-2-iodobenzene (1 mmol), amino phenol (1 mmol), Pd(OAc)2 (5 mol%), xantphos (5 mol%) and DBU (2.5 mmol). The tube was purged with argon. Then DMF (10 V) was added followed by the addition of Co2(CO)8 (0.25 mmol). The tube was closed with seal plug instantly. The reaction tube was placed in a pre heated oil bath at 150 0C for 16 h. On completion, the reaction mixture was cooled to room temperature, added water and ethyl acetate (1:1). Precipitated solid was filtered through a Celite bed. The bed was washed thoroughly with ethyl acetate. Organic layer was separated. Aqueous layer extracted with EtOAc. The combined organic layers were washed with water, brine, dried over anhydrous sodium sulphate. Organic layer was concentrated under reduced pressure and purified by flash column chromatography on silica gel (230-400 mesh) with ethyl acetate and petroleum ether as eluent to afford the corresponding dibenzoxazepinones.Example 8A 4-fluoro-3-iodobenzaldehyde A mixture of
Computed Properties
Molecular Weight:236.02
XLogP3:3
Hydrogen Bond Acceptor Count:1
Exact Mass:235.94983
Monoisotopic Mass:235.94983
Heavy Atom Count:9
Complexity:94.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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