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Isothipendyl

Isothipendyl structure

CAS No:
482-15-5
Formula:
C16H19N3S
Chemical Name:
Isothipendyl
Synonyms:
10H-Pyrido[3,2-b][1,4]benzothiazine-10-ethanamine,N,N,α-trimethyl-;10H-Pyrido[3,2-b][1,4]benzothiazine,10-[2-(dimethylamino)propyl]-;N,N,α-Trimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-ethanamine;D 201;AY 56012;Dimethylaminoisopropylazaphenothiazine;10-[2-(Dimethylamino)propyl]-10H-pyrido[3,2-b][1,4]benzothiazine;10-(2-Dimethylaminopropyl)-9-thia-1,10-diazaanthracene;10-(2-Dimethylaminopropyl)thiophenylpyridylamine;Isothipendyl;10-(2-Dimethylamino-2-methylethyl)-10H-pyrido[3,2-b][1,4]benzothiazine;10-(2-Dimethylaminopropyl)-1-azaphenothiazine;N-Dimethylaminoisopropylthiophenylpyridylamine;Udantol;Odantol;(±)-Isothipendyl
Categories:
Organic Chemistry > Heterocyclic Ring

Description

Solid

Isothipendyl is a tertiary amino compound and an aromatic amine.|Isothipendyl is an antihistamine and anticholinergic used as an antipruritic.

Isothipendyl Basic Attributes

Molecular Weight：

285.409

Exact Mass：

285.41

EC Number：

207-578-5

DSSTox ID：

DTXSID5048267

ATC Code：

D04AA22|D - Dermatologicals|R - Respiratory system

Characteristics

PSA：

44.7

XLogP3：

3.69940

Appearance：

Solid

Density：

1.167g/cm3

Melting Point：

213-216

Boiling Point：

172.5 °C

Flash Point：

208.6ºC

Refractive Index：

1.62

Vapor Pressure：

2.63E-07mmHg at 25°C

Toxicity：

LD50 in mice (mg/kg): 65 ±2 i.p.; 222 ±18 orally (Schlichtegroll)

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

Drug Indication：

For the topical treatment of itching associated with allergic reactions.

Pharmacology：

Isothipendyl, an azaphenothiazine derivative, competitively binds to histamine (H1) receptors, resulting in inhibition of the pharmacological effects of histamines. It also has some sedative, anticholinergic and antiserotoninergic effects.

MeSH：

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only. (See all compounds classified as Histamine Antagonists.)

Mechanism of Action：

Isothipendyl is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

MeSH Entry Terms：

10-(2-dimethylamino-2-methylethyl)-10H-pyrido(3,2- b)(1,4)benzothiazine

Isothipendyl Use and Manufacturing

Uses

Antihistaminic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:285.4
XLogP3:3.5
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:285.12996879
Monoisotopic Mass:285.12996879
Topological Polar Surface Area:44.7
Heavy Atom Count:20
Complexity:323
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Isothipendyl

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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ISOTHIPENDYL

CAS No.: 482-15-5

Grade: Industrial Grade

Content: 99%

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