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Dihydroberberine

Dihydroberberine structure

CAS No:
483-15-8
Formula:
C20H19NO4
Chemical Name:
Dihydroberberine
Synonyms:
6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine,5,8-dihydro-9,10-dimethoxy-;Berbine,13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-;Berberine,dihydro-;5,8-Dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine;Dihydroberberine;7,8-Dihydroberberine;Dihydroumbellatine;NSC 331264;858716-33-3
Categories:
Organic Chemistry > Heterocyclic Ring

Description

Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1].

Solid

Dihydroberberine Basic Attributes

Molecular Weight：

337.375

Exact Mass：

337.37

NSC Number：

331264

DSSTox ID：

DTXSID70197476

HScode：

2934999090

Characteristics

PSA：

40.2

XLogP3：

5.09

Appearance：

Solid

Density：

1.4±0.1 g/cm3

Melting Point：

223-224 °C (decomp)

Boiling Point：

557.8±50.0 °C at 760 mmHg

Flash Point：

170.7±27.3 °C

Refractive Index：

1.679

Vapor Pressure：

1.77E-12mmHg at 25°C

Drug Information

MeSH Entry Terms：

dihydroberberine

Computed Properties

Molecular Weight:337.4
XLogP3:3.5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:337.13140809
Monoisotopic Mass:337.13140809
Topological Polar Surface Area:40.2
Heavy Atom Count:25
Complexity:538
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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