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ANGIOTENSINI,HUMAN

ANGIOTENSINI,HUMAN structure

CAS No:
484-42-4
Formula:
C62H89N17O14
Chemical Name:
ANGIOTENSINI,HUMAN
Synonyms:
ANGI;DRVYIHPFHL;ANGIOTENSINI;human,mouse,rat;H2N-DRVYIHPFHL-OH;ANGIOTENSI,HUMAN;AngiotensinI【rat】;Angiotensin-(1-10);HYPERTENSINIHUMAN;ANGIOTENSINI,HUMAN
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Angiotensin I is a ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids. It has a role as a neurotransmitter agent and a human metabolite. It is a tautomer of an angiotensin I dizwitterion.|A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.

ANGIOTENSINI,HUMAN Basic Attributes

Molecular Weight：

1296.48

Exact Mass：

1295.677

UNII：

9C880YQG7C

Characteristics

PSA：

496

XLogP3：

-1.1

Appearance：

White Powder

Density：

1.43±0.1 g/cm3(Predicted)

Water Solubility：

soluble to 1 mg/ml in water.

Storage Conditions：

-15°C

Collision Cross Section：

387.3 Å² [M+2H]2+ [CCS Type: DT, Method: stepped-field]|474.71 Å² [M+3H]3+ [CCS Type: DT, Method: stepped-field]|549.24 Å² [M+4H]4+ [CCS Type: DT, Method: stepped-field]|357.31 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]

Drug Information

MeSH Entry Terms：

Angiotensin I

Computed Properties

Molecular Weight:1296.5
XLogP3:-1.1
Hydrogen Bond Donor Count:16
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:37
Exact Mass:1295.67749058
Monoisotopic Mass:1295.67749058
Topological Polar Surface Area:496
Heavy Atom Count:93
Complexity:2550
Defined Atom Stereocenter Count:11
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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