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Flunarizine hydrochloride

Flunarizine hydrochloride structure

CAS No:
30484-77-6
Formula:
C26H26F2N2.2ClH
Chemical Name:
Flunarizine hydrochloride
Synonyms:
Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-,hydrochloride (1:2);Piperazine,1-[bis(p-fluorophenyl)methyl]-4-cinnamyl-,dihydrochloride,(E)-;Piperazine,1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-,dihydrochloride,(E)-;Piperazine,1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]-,dihydrochloride;Flunarizine hydrochloride;Flunarizine dihydrochloride;R 14950;Gradient;Flugeral;Fluxarten;Dinaplex;Issium;Flunagen;Mondus;Flunarl;(E)-1-[Bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Flunarizine is a selective calcium entry blocker.Target: Calcium ChannelFlunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with other actions including histamine H1 receptor blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks

Flunarizine hydrochloride Basic Attributes

Molecular Weight：

477.41700

Exact Mass：

476.16000

EC Number：

248-203-5

HScode：

2933599090

Characteristics

PSA：

6.48000

XLogP3：

6.86500

Appearance：

White crystalline powder, odorless and tasteless

Melting Point：

251.5 °C

Boiling Point：

511.3ºC at 760 mmHg

Flash Point：

263ºC

Water Solubility：

chloroform/methanol (9:1): 50 mg/mL, clear, colorless

Storage Conditions：

2-8ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22

RTECS Number：

TK9187000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Flunarizine hydrochloride Use and Manufacturing

1. Antipsychotic, H1 antihistamine
2. Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.

Material

Tetrafluoroboric acid

Drug Function and Efficacy

This product is a calcium channel blocker, which can prevent cell damage caused by pathological intracellular calcium overload due to ischemia and other reasons; 1. Relieve vasospasm, and have a lasting inhibitory effect on persistent vasospasm caused by vasoconstrictor substances, especially on the basilar artery and internal carotid artery; 2. Vestibular inhibitory effect, which can increase the blood flow of cochlear arterioles and improve vestibular organ circulation; 3. Anti-epileptic effect, which can block the pathological calcium overload of nerve cells to prevent paroxysmal depolarization and cell discharge, thereby avoiding epileptic seizures; 4. Protect the myocardium and significantly reduce ischemic myocardial damage; 5. It also has the effect of improving renal function and can be used for chronic renal failure; in addition, this product also has anti-histamine effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Flunarizine Hydrochloride Tablets
Ingredients	Main ingredient: Flunarizine hydrochloride. Molecular formula: C26H26F2N2·2HCl Molecular weight: 477.42
Indication	1. When used in combination with alcohol, hypnotics or sedatives, the sedative effect is aggravated. 2. When used in combination with phenytoin sodium and carbamazepine, the blood concentration of flunarizine can be reduced. 3. When flunarizine is used in combination with radiotherapy patients, it can increase the killing power of tumor cells. 4. On the basis of anti-epileptic drug treatment, the addition of flunarizine can improve the anti-epileptic effect.
Specifications	6 mg (calculated as flunarizine)
Manufacturer	Zhejiang Medicine Co., Ltd.

Flunarizine Hydrochloride Dropping Pills
Ingredients	Flunarizine hydrochloride.
Indication	When this product is used in combination with alcohol, hypnotics or sedatives, excessive sedation of the central nervous system may occur. This product is not contraindicated for patients using beta-receptor blockers. When used in combination with phenytoin sodium and carbamazepine, the blood concentration of flunarizine is reduced.
Specifications	Each pill contains 1.25 mg of flunarizine
Manufacturer	NanChang Helioeast Pharmaceutical Co., Ltd.

Flunarizine Hydrochloride Capsules
Ingredients	Flunarizine hydrochloride Chemical name: (E)-1-[bis(4-fluorophenyl)methyl]-4-(2-propenyl-3-phenyl)-piperazine dihydrochloride Molecular formula: C26H26F2N22HCL Molecular weight: 477.42.
Indication	When this product is used in combination with alcohol, hypnotics or sedatives, excessive sedation may occur. This product is not contraindicated for patients using beta-receptor blockers.
Specifications	5mg (based on C26H26F2N2)
Manufacturer	Xinxiang Xinhui Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shanxi Zhendong Anxin Biopharmaceutical Co., Ltd.

China
Active
Jinyao Pharmaceutical Co., Ltd.

China
Active
Shandong Guomao Enterprise Management Co., Ltd.

China
Active

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CAS No.: 30484-77-6

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Flunarizine dihydrochloride

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Flunarizine dihydrochloride cas 30484-77-6

CAS No.: 30484-77-6

Grade: Analytical Reagent

Content: 99%

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Guide of Flunarizine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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