Fluorobenzene | 462-06-6, Fluorobenzene Formula

Description

colourless liquid Fluorobenzene is a colorless liquid.

Fluorobenzene appears as a clear, colorless liquid with a characteristic aromatic odor. About the same density as water. Flash point 5°F. Vapors heavier than air. May irritate the skin, eyes, and mucous membranes. Used as an insecticide, larvacide and as a reagent for plastic or resin polymers.

Fluorobenzene appears as a clear, colorless liquid with a characteristic aromatic odor. About the same density as water. Flash point 5°F. Vapors heavier than air. May irritate the skin, eyes, and mucous membranes. Used as an insecticide, larvacide and as a reagent for plastic or resin polymers.|Monofluorobenzene is the simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.|Derivatives of BENZENE that contain FLUORINE.

Fluorobenzene Basic Attributes

Molecular Weight：

96.1

Exact Mass：

96.10

BRN：

1236623

EC Number：

207-321-7

UNII：

G3TSZ68K12

NSC Number：

68416

UN Number：

2387

DSSTox ID：

DTXSID4025329

HScode：

2903999090

Characteristics

PSA：

0

XLogP3：

2.27

Appearance：

Clear colorless Liquid

Density：

1.04653 g/cm³ @ Temp: 40 °C

Melting Point：

-42.2 °C

Boiling Point：

84.7 °C

Flash Point：

9 °F

Refractive Index：

1.473

Water Solubility：

H2O: INsoluble

Storage Conditions：

0-6°C

Vapor Pressure：

60 mm Hg at 67.3° F ; 100 mm Hg at 86.7° F (NTP, 1992)

Vapor Density：

3.31 (vs air)

Toxicity：

Oral-Rat LD50: 4399 mg/kg; inhalation-mouse 45 g/m3/ 2 hours

Flammability characteristics：

Inflammable in case of open flame, high temperature, oxidant; burning produces toxic fluoride smoke

Explosive limit：

1.3-8.9%(V)

OH：

6.90e-13 cm3/molecule*sec

Henrys Law Constant：

0.01 atm-m3/mole

Air and Water Reactions：

Highly flammable. Slightly soluble in water.

Reactive Group：

Aryl Halides

Reactivity Alerts：

Highly Flammable

Reactivity Profile：

Incompatible with strong oxidizing agents. (NTP, 1992)

Safety Information

Packing level：

II

Hazard category：

3

Transport codes：

UN 2387 3/PG 2

wgk germany：

2

hazard class code：

36/37/38-11-39/23/24/25-23/24/25-52/53-36

safety instructions：

16-26-36-7-33-29-45-36/37-61-7/9

RTECS Number：

DA0800000

Marks：

F,Xi,T

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Hazard note：

Flammable

Stability/Shelf Life：

Stable. Incompatible with oxidizing agents. Highly flammable - note low flash point.

Precautionary statement(s)：

P210-P273-P305 + P351 + P338

Hazard Statements：

H225-H319-H412

Fire Hazards：

Special Hazards of Combustion Products: Burning in open flame can form toxic hydrogen fluoride gases. Behavior in Fire: Heavy vapor can travel a considerable difference to a source of ignition and flash back. (USCG, 1999)|Flammable - 3rd degree

GHS Classification：

|Danger|H225 (99.62%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P264, P273, P280, P303+P361+P353, P305+P351+P338, P310, P337+P313, P370+P378, P391, P403+P235, and P501|Aggregated GHS information provided by 266 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fire Fighting：

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. SMALL FIRE: Dry chemical, CO2, water spray or regular foam. LARGE FIRE: Water spray, fog or regular foam. Do not use straight streams. Move containers from fire area if you can do it without risk. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016)

Isolation and Evacuation：

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Nonfire Spill Response：

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Personal Protective Equipment：

Organic vapor-acid gas respirator where appropriate; neoprene or vinyl gloves; chemical safety spectacles, plus face shield where appropriate; rubber footwear; apron or impervious clothing for splash protection; hard hat. (USCG, 1999)

Toxicity

Toxicity class：

moderately toxic

Drug Information

Health Hazards：

Irritating to skin, eyes and mucous membranes. Repeated exposure of skin may cause dermatitis due to defatting action. Chronic inhalation of vapors or mist may result to damage to lungs, liver and kidneys. Acute vapor exposures can cause symptoms ranging from coughing to transient anesthesia and central nervous system depression. (USCG, 1999)

First Aid：

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

MeSH Entry Terms：

Fluorobenzene

Fluorobenzene Use and Manufacturing

Methods of Manufacturing

1. Derived from aniline through Schiemann reaction. After aniline is salted with 31% hydrochloric acid, the temperature is lowered to -8°C, and sodium nitrite solution is added for diazotization. The diazonium liquid is cooled to -10°C, and fluoroboric acid solution is added to generate diazonium fluoroborate with less solubility, which is filtered. The diazobenzene fluoroborate is dried and then pyrolyzed. At the same time, the generated fluorobenzene is distilled out, and the distillate is washed with sodium hydroxide solution, then washed with water, dried and then distilled to obtain a finished product with a yield of about 53%. This method consumes a lot of boric acid, has a lot of waste gas, and has a higher cost. 2. Use dry sodium nitrite and aniline to act in anhydrous hydrogen fluoride, and then keep the diazonium compound solution below 40°C with a yield of 80%. The advantages of this method are low cost and less waste gas. 3. The trifluoroacetic anhydride method takes trifluoroacetic anhydride and cyclohexane as raw materials, undergoes addition reaction, and then reacts with hydrogen fluoride to produce 1, 1-difluorocyclohexane and trifluoroacetic acid; 1, 1-difluorocyclic Hexane is then dehydrogenated and dehydrogenated to obtain fluorobenzene.

Uses

Mainly used for the preparation of antipsychotic drug haloperidol, etc., also used as an insecticide, and for the identification of plastics and resin polymers

Manufacturing Info：

Benzene, fluoro-: ACTIVE

Use Classification：

Fire Hazards -> Flammable - 3rd degree

Computed Properties

Molecular Weight:96.10
XLogP3:2.3
Hydrogen Bond Acceptor Count:1
Exact Mass:96.037528322
Monoisotopic Mass:96.037528322
Heavy Atom Count:7
Complexity:46.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Cyclohexane

Tetrafluoroboric acid

2-Fluorobenzoic acid

Aniline

Sodium nitrite

Hydrofluoric acid

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