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Etofenamate

Etofenamate structure

CAS No:
30544-47-9
Formula:
C18H18F3NO4
Chemical Name:
Etofenamate
Synonyms:
Benzoic acid,2-[[3-(trifluoromethyl)phenyl]amino]-,2-(2-hydroxyethoxy)ethyl ester;Anthranilic acid,N-(α,α,α-trifluoro-m-tolyl)-,2-(2-hydroxyethoxy)ethyl ester;Etofenamate;Rheumon;2-(2-Hydroxyethoxy)ethyl flufenamate;Bay-d 1107;Glasel;B 577;Traumon Gel;Bayrogel;Rheumon gel;WHR 5020;TV 485;2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester;Reumon
Categories:
Organic Chemistry > Amides

Description

Etofenamate is a non-steroidal anti-inflammatory drug used for the treatment joint and muscular pain.

2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester is a benzoate ester.|Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID).

Etofenamate Basic Attributes

Molecular Weight：

369.33

Exact Mass：

369.33

EC Number：

250-231-8

UNII：

KZF0XM66JC

DSSTox ID：

DTXSID2045448

ATC Code：

M02AA06|M - Musculo-skeletal system

HScode：

2922509090

Characteristics

PSA：

67.8

XLogP3：

4.7

Density：

1.3±0.1 g/cm3

Melting Point：

<25 °C

Boiling Point：

132.5 °C

Flash Point：

226.6±28.7 °C

Refractive Index：

1.552

Water Solubility：

Practically insoluble in water, miscible with ethanol (96 per cent) and with ethyl acetate.

Storage Conditions：

Refrigerator

Toxicity：

LD50 in male, female rats (mg/kg): 292, 470 orally; 140, 226 i.v.; 373, 397 i.p.; 643, 568 s.c. (Jacobi)

Safety Information

Precautionary statement(s)：

P264, P270, P273, P301+P310, P321, P330, P391, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 28 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

2-(2-hydroxyethoxy)-ethyl-N-(alpha,alpha,alpha-trifluoro- m-tolyl)anthranilate

Etofenamate Use and Manufacturing

Medication used to alleviate joint and muscle pain.

Computed Properties

Molecular Weight:369.3
XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:369.11879254
Monoisotopic Mass:369.11879254
Topological Polar Surface Area:67.8
Heavy Atom Count:26
Complexity:433
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It is a non-steroidal anti-inflammatory drug of the fenamic acid class that can inhibit cyclooxygenase and esteroxidase, thereby reducing the effects of prostaglandins and other inflammatory mediators, and exerting its anti-inflammatory and analgesic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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Registered Holders

Beijing Ansenbo Pharmaceutical Technology Co., Ltd.

China
Active
Bayer Healthcare Company Ltd.

China
Active
BAYER AG

European Union
Active

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Recommended Suppliers of Etofenamate

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CN
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Factory price and high quality Etofenamate cas 30544-47-9

CAS No.: 30544-47-9

Grade: Pharmaceutical Grade

Content: 99%

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Shandong zhishang chemical Co.,Ltd Contact Supplier

CN
YRS

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Manufactory Supplier of Dichloromethane,Linocaine hydrochloride

30544-47-9 Etofenamate white powder

Unit Price: nullnull /null null

CAS No.: 30544-47-9

Grade: Industrial Grade

Content: 98%

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Guide of Etofenamate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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Etofenamate

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