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5-Hydroxyflavone

5-Hydroxyflavone structure

CAS No:
491-78-1
Formula:
C15H10O3
Chemical Name:
5-Hydroxyflavone
Synonyms:
4H-1-Benzopyran-4-one,5-hydroxy-2-phenyl-;Flavone,5-hydroxy-;5-Hydroxy-2-phenyl-4H-1-benzopyran-4-one;5-Hydroxyflavone;5-Hydroxy-2-phenylchromone;Primuletin;NSC 26745;5-Hydroxy-2-phenylchromen-4-one;5-Hydroxy-2-phenyl-4H-chromen-4-one
Categories:
Biochemical Engineering > Plant Extracts

Description

5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells[1].

5-Hydroxyflavone is a member of flavones.

5-Hydroxyflavone Basic Attributes

Molecular Weight：

238.24

Exact Mass：

238.24

BRN：

194429

EC Number：

207-743-1

UNII：

378AE9MHL3

NSC Number：

26745

DSSTox ID：

DTXSID90197690

HScode：

29329990

Characteristics

PSA：

46.5

XLogP3：

3.16560

Density：

1.34g/cm3

Melting Point：

156-157 °C

Boiling Point：

425ºC at 760 mmHg

Flash Point：

165.4ºC

Refractive Index：

1.666

Vapor Pressure：

7.97E-08mmHg at 25°C

Collision Cross Section：

147.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36-36/37/39-27-37

Marks：

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

Drug Information

Metabolism/Metabolites：

5-Hydroxyflavone has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-(4-oxo-2-phenylchromen-5-yl)oxyoxane-2-carboxylic acid.

MeSH Entry Terms：

5-hydroxyflavone

5-Hydroxyflavone Use and Manufacturing

Uses

Reactant involved in:• ;Condensation reactions for synthesis of copper(II) complexes as bioactive molecules to combat antioxidants1• ;Thermal behavior studies of vanadyl complexes with flavone derivatives in terms of insulin-mimetic agents2• ;O-methylation with di-Me carbonate3• ;DFT studies on excited-state intramolecular proton transfer4

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:238.24
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:238.062994177
Monoisotopic Mass:238.062994177
Topological Polar Surface Area:46.5
Heavy Atom Count:18
Complexity:355
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Hot Searches: tricalcium phosphate; 1-pentanol; sucrose acetate isobutyrate; menthone ghs symbol; remeron generic name; nitrogen trioxide

Guide of 5-Hydroxyflavone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

5-Hydroxyflavone

SDS

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