Amezinium metilsulfate
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Amezinium metilsulfate
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CAS No:
30578-37-1
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Formula:
C11H12N3O.CH3O4S
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Chemical Name:
Amezinium metilsulfate
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Synonyms:
Pyridazinium,4-amino-6-methoxy-1-phenyl-,methyl sulfate (1:1);Pyridazinium,4-amino-6-methoxy-1-phenyl-,methyl sulfate;1-Phenyl-4-amino-6-methoxypyridazinium methyl sulfate;Lu 1631;Amezinium metilsulfate;Regulton;Amezinium methyl sulfate;Risumic;Supratonin
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CAS No:
Description
Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Target: alpha and beta-1 receptorsAmezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25). During spinal/epidural anaesthesia 5 mg amezinium is given i.v. i
Amezinium metilsulfate is an azaheterocycle sulfate salt of amezinium. It is a sympathomimetic drug which suppresses noradrenaline reuptake and thereby elevating blood pressure. It is used for the treatment of low blood pressure in patients undergoing dialysis. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor, an antihypotensive agent, a sympathomimetic agent and an adrenergic uptake inhibitor. It contains an amezinium.
Amezinium metilsulfate Basic Attributes
313.33
313.07300
250-248-0
03NR868ICX
DTXSID00184657
C - Cardiovascular system
2933990090
Characteristics
127
1.70410
1676 °C (decomp)
LD50 in mice, rats (mg/kg): 1630, 1410 orally; 40.4, 45.5 i.v. (Teschendorf)
Safety Information
UR6066500
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 43 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)
4-amino-6-methoxy-1-phenylpyridazinium methylsulfate
Computed Properties
Molecular Weight:313.33
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:313.07324176
Monoisotopic Mass:313.07324176
Topological Polar Surface Area:127
Heavy Atom Count:21
Complexity:285
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes