3-FLUORO-4-METHOXYPHENYLACETONITRILE
-
3-FLUORO-4-METHOXYPHENYLACETONITRILE
structure -
-
CAS No:
404-90-0
-
Formula:
C9H8FNO
-
Chemical Name:
3-FLUORO-4-METHOXYPHENYLACETONITRILE
-
Synonyms:
4-(Cyanomethyl)-2-fluoroanisole;3-Fluoro-4-Methoxylacetonitrile;3-FLUORO-4-METHOXYBENZYLCYANIDE;3-FLUORO-4-METHOXYPHENYLACETONITRILE;3-Fluoro-4-Methoxylphenylacetonitrile;3-Fluoro-4-methoxyphenylacetonitrile98%;2-(3-fluoro-4-methoxyphenyl)acetonitrile;Benzeneacetonitrile,3-fluoro-4-Methoxy-;2-(3-fluoro-4-methoxy-phenyl)acetonitrile;2-(3-fluoro-4-methoxy-phenyl)ethanenitrile
- Categories:
-
CAS No:
Characteristics
33
1.3
1.1±0.1 g/cm3
46-48°C
270.6°C at 760 mmHg
117.5±23.2 °C
1.501
0.00676mmHg at 25°C
Safety Information
III
6.1
3439
R20/21/22
S26-S36/37/39
Xi: Irritant;
P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501
H301
3-FLUORO-4-METHOXYPHENYLACETONITRILE Use and Manufacturing
To a suspension of t-BuOK (25.3 g, 0.207 mol) in THF (150 mL) was added a solution of TosMIC (20.3 g, 0.104 mol) in THF (50 mL) at -78° C. The mixture was stirred for 15 minutes, treated with a solution of 3-fluoro-4-methoxy-benzaldehyde (8.00 g, 51.9 mmol) in THF (50 mL) dropwise, and continued to stir for 1.5 hours at -78° C. To the cooled reaction mixture was added methanol (50 mL). The mixture was heated at reflux for 30 minutes. Solvent of the reaction mixture was removed to give a crude product, which was dissolved in water (200 mL). The aqueous phase was extracted with EtOAc (100 mL.x.3). The combined organic layers were dried and evaporated under reduced pressure to give crude product, which was purified by column chromatography (petroleum ether/ethyl acetate 10:1) to afford 2-(3-fluoro-4-methoxyphenyl)acetonitrile (5.0 g, 58percent). To a suspension of t-BuOK (25.3 g, 0.207 mol) in THF (150 mL) was added a solution of TosMIC (20.3 g, 0.104 mol) in THF (50 mL) at -78° C. Example 15
Computed Properties
Molecular Weight:165.16
XLogP3:1.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:165.058992041
Monoisotopic Mass:165.058992041
Topological Polar Surface Area:33
Heavy Atom Count:12
Complexity:186
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 3-FLUORO-4-METHOXYPHENYLACETONITRILE
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamine
Learn More Other Chemicals
-
4-Mercaptophenylboronic acid
237429-33-3
-
(4-BENZYLOXYCARBONYLPHENYL)BORONIC ACID
184000-11-1
-
(4-chlorophenyl)methoxy-trimethylsilane
14856-74-7
-
4,4'-DIBROMO-TRANS-STILBENE Formula
18869-30-2
-
(R)-(-)-1-[(S)-2-(DI(3,5-DIMETHYL-4-METHOXYPHENYL)PHOSPHINO)FERROCENYL]ETHYLDICYCLOHEXYLPHOSPHINE Formula
360048-63-1
-
4-BENZYLOXY-3-CHLOROPHENYLBORONIC ACID Formula
845551-44-2
-
4,5-dichloro-4,5-difluoro-2,2-bis(trifluoromethyl)-1,3-dioxolane Structure
60644-92-0
-
2-Methyl-2H-indazole-4-boronic acid pinacol ester Structure
885698-95-3
-
What is 3-HEPTAFLUOROPROPYL-5-METHYL-4-NITROPYRAZOLE
82633-69-0
-
What is 2,6-Dinitro-4-(trifluoromethyl)phenol
393-77-1
3-FLUORO-4-METHOXYPHENYLACETONITRILE
SDSRequest for Quotation