 Home > Encyclopedia > 2,5-DIBROMOTHIAZOLE

2,5-DIBROMOTHIAZOLE

2,5-DIBROMOTHIAZOLE structure

CAS No:
4175-78-4
Formula:
C3HBr2NS
Chemical Name:
2,5-DIBROMOTHIAZOLE
Synonyms:
NSC222407;2,5-DIBROMOTHIAZOLE;Thiazole,2,5-dibroMo-;2,5-Dibromothiazole,97%;2,5-DIBROMOTHIAZOLE95%;2,5-Dibromo-1,3-thiazole
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Request for Quotation

Description

White to brown crystalline powder

2,5-DIBROMOTHIAZOLE Basic Attributes

Molecular Weight：

242.916

Exact Mass：

240.819626

NSC Number：

222407

DSSTox ID：

DTXSID40310094

HScode：

2934100090

Characteristics

PSA：

41.1

XLogP3：

Density：

2.3±0.1 g/cm3

Melting Point：

45-49 °C(lit.)

Boiling Point：

242.8°C at 760 mmHg

Flash Point：

100.6±19.8 °C

Refractive Index：

1.650

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36

Marks：

Xi: Irritant;

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2,5-DIBROMOTHIAZOLE Use and Manufacturing

Methods of Manufacturing

A solution of 2-amino-5-bromothiazole (1-21) (5.5 g, 30.72 mmol) in acetonitrile (50 mL) was treated with copper (II) bromide (3.43 g, 15.36 mmol) and isoamyl nitrite (4.9 mL, 36.87 mmol), and the resulting reaction mixture was heated at 60°C for 4 hours. The volatiles were removed by evaporation, and the obtained residue was diluted with water (50 mL) , followed by extraction with ethyl acetate (25 mL x 2), The combined organic layers were washed with brine (50 mL) , dried over anhydrous Na2S04 and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (60-120 mesh) using 10percent EtOAc in hexanes to give the desired product 1-22 (5.05 g, 68percent) as a yellow liquid; LCMS : m/z 243.6 [M+2].Step I: 2, 5-dibromothiazole (1-22) Compound thiazole (1 mmol, 84.9 mg)Carbon tetrabromide (2.1 mmol, 696.4 mg) was placed in a 10 mL round bottom flask.Added 5 mL of N, N-dimethylformamide and sodium tert-butoxide (4.0 mmol, 384.4 mg).Stir at room temperature for 3 hours, TLC monitored the endpoint of the reaction.The mixture was poured into water and extracted with dichloromethane. The organic phase was collected and dried. The dichloromethane was removed by rotary evaporation at low temperature to obtain a crude product.The crude product was subjected to silica gel column chromatography with petroleum ether and ethyl acetate as eluent (volume ratio = 30:1).2, 5-Dibromothiazole (colorless liquid, slow crystallisation at low temperature, 186.4 mg, yield 77percent) was obtained.

Uses

Used as a building block in material science.1,2 2,5-Dibromothiazole is used in the preparation of arylthiazolylpiperidine derivatives and analogs for use as survival motor neuron (SMN) protein production modulators.

Computed Properties

Molecular Weight:242.92
XLogP3:3
Hydrogen Bond Acceptor Count:2
Exact Mass:242.81760
Monoisotopic Mass:240.81965
Topological Polar Surface Area:41.1
Heavy Atom Count:7
Complexity:70
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2,5-DIBROMOTHIAZOLE

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2,5-Dibromo-1,3-thiazole

CAS No.: 4175-78-4

Content: 99.00%

Inquiry
NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

2,5-DIBROMOTHIAZOLE

CAS No.: 4175-78-4

Grade: Industrial Grade

Content: 99%

Inquiry
Shandong Changyuan Chemical Co., Ltd. Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of Chemical solvents, chemical intermediates, custom chemicals

2,5-Dibromothiazole CAS: 4175-78-4 98% Heterocyclic Building Block for Material Science & Organic Synthesis

CAS No.: 4175-78-4

Grade: Industrial Grade

Content: 99%

Inquiry