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Tolonidine

Tolonidine structure

CAS No:
4201-22-3
Formula:
C10H12ClN3
Chemical Name:
Tolonidine
Synonyms:
1H-Imidazol-2-amine,N-(2-chloro-4-methylphenyl)-4,5-dihydro-;2-Imidazoline,2-(2-chloro-p-toluidino)-;N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine;2-(2-Chloro-4-methylphenylamino)-2-imidazoline;2-(2-Chloro-4-methylanilino)-2-imidazoline;Tolonidine;St 375
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1].

Tolonidine is a substituted aniline.

Tolonidine Basic Attributes

Molecular Weight：

209.677

Exact Mass：

209.68

UNII：

I4O795Q03O

DSSTox ID：

DTXSID80194815

ATC Code：

C - Cardiovascular system

HScode：

2933290090

Characteristics

PSA：

36.4

XLogP3：

1.85690

Density：

1.31g/cm3

Melting Point：

148-150 °C

Boiling Point：

314ºC at 760 mmHg

Flash Point：

143.7ºC

Refractive Index：

1.637

Drug Information

MeSH Entry Terms：

2-(2-chloro-p-toluidino)-2-imidazoline nitrate

Computed Properties

Molecular Weight:209.67
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:209.0719751
Monoisotopic Mass:209.0719751
Topological Polar Surface Area:36.4
Heavy Atom Count:14
Complexity:229
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes