 Home > Encyclopedia > 3-Deoxyglucosone

3-Deoxyglucosone

3-Deoxyglucosone structure

CAS No:
4084-27-9
Formula:
C6H10O5
Chemical Name:
3-Deoxyglucosone
Synonyms:
D-erythro-Hexos-2-ulose,3-deoxy-;D-erythro-Hexosulose,3-deoxy-;3-Deoxy-D-erythro-hexos-2-ulose;3-Deoxyglucosone;3-Deoxy-D-erythro-hexosulose;2-keto-3-Deoxyglucose;3-Deoxy-D-glucosone
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes[1][2][3].

3-deoxyglucosone is a deoxyketohexose comprising the open-chain form of D-glucose lacking the -OH group at the 3-position and having the keto group at the 2-position. It is a deoxyketohexose and a deoxyglucose.

3-Deoxyglucosone Basic Attributes

Molecular Weight：

162.141

Exact Mass：

162.14

UNII：

EXV5374VEY

DSSTox ID：

DTXSID00193820

HScode：

29329990

Characteristics

PSA：

94.8

XLogP3：

-2.38

Density：

1.4±0.1 g/cm3

Melting Point：

73-75ºC

Boiling Point：

400.1±45.0 °C at 760 mmHg

Flash Point：

209.9±25.2 °C

Refractive Index：

1.512

Water Solubility：

Soluble in water, methanol or hot ethanol.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

Marks：

Stability/Shelf Life：

Hygroscopic

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

2-keto-3-deoxyglucose

3-Deoxyglucosone Use and Manufacturing

An intermediate in the Maillard reaction of proteins with glucose, which is metabolised to 3-Deoxyfructose. An intermediate in the formation of pyrraline, which might contribute to a pathological effect, such as carcinogenesis

Computed Properties

Molecular Weight:162.14
XLogP3:-2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:162.05282342
Monoisotopic Mass:162.05282342
Topological Polar Surface Area:94.8
Heavy Atom Count:11
Complexity:144
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Deoxyglucosone

LEADER BIOCHEMICAL GROUP Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

China Most Professional Factory Supply High Qulity 3-DEOXYGLUCOSONE CAS 4084-27-9

CAS No.: 4084-27-9

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

3-Deoxyglucosone

CAS No.: 4084-27-9

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

3-DEOXYGLUCOSONE 99% see COA kanbei

CAS No.: 4084-27-9

Content: 99%

Inquiry