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Phenoxyacetic acid

Phenoxyacetic acid structure

Phenoxyacetic acid 

structure
  • CAS No:

    122-59-8

  • Formula:

    C8H8O3

  • Chemical Name:

    Phenoxyacetic acid

  • Synonyms:

    Acetic acid,2-phenoxy-;Acetic acid,phenoxy-;2-Phenoxyacetic acid;Glycolic acid phenyl ether;Phenoxyacetic acid;Phenoxyethanoic acid;POA;NSC 9810;2-Phenyloxyacetic acid

  • Categories:

    Cosmetic Ingredient  >  Perfuming

Description

Phenoxyacetic acid is an endogenous metabolite.


Phenoxyacetic acid appears as light tan powder or white solid. (NTP, 1992)|Solid|Colourless needle-like crystals; sour sweet odour


Phenoxyacetic acid appears as light tan powder or white solid. (NTP, 1992)|Phenoxyacetic acid is a monocarboxylic acid that is the O-phenyl derivative of glycolic acid. A metabolite of 2-phenoxyethanol, it is used in the manufacture of pharmaceuticals, pesticides, fungicides and dyes. It has a role as a human xenobiotic metabolite, an Aspergillus metabolite, a plant growth retardant and an allergen. It is a monocarboxylic acid and an aromatic ether. It derives from a glycolic acid. It is a conjugate acid of a phenoxyacetate.

Phenoxyacetic acid Basic Attributes

152.15

152.15

907949

204-556-7

YRC253429Q

9810

3347

DTXSID9025873

29189090

Characteristics

46.5

1.34 (LogP)

White Granular Powder, Granules, or Prills

1.2±0.1 g/cm3

98.5 °C

285 °C

165 °C

1.541

H2O: 0.1-0.5 g/100 mL at 17 ºC;ethanol: soluble 10%, clear, colorless

Store below +30°C.

0.00135mmHg at 25°C

Slightly soluble in water.

Acids, Carboxylic

PHENOXYACETIC ACID reacts exothermically with all bases, both organic (for example, the amines) and inorganic.

Safety Information

NONH for all modes of transport

3

22-36/37/38

26-36-37/39

AJ2230000

Xn

Stable. Substances to be avoided include strong bases, strong oxidizing agents. Combustible.

P261-P305 + P351 + P338

H302-H315-H319-H335

Flash point data for this chemical are not available; however it is probably combustible. (NTP, 1992)

|Warning|H302 (96.83%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 257 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

ACUTE/CHRONIC HAZARDS: This compound is a mild skin irritant. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

phenoxyacetic acid

Phenoxyacetic acid Use and Manufacturing

Methods of Manufacturing

The preparation method is to add phenol to the reaction kettle, add an equimolar aqueous solution of sodium hydroxide, dropwise add chloroacetic acid and aqueous sodium hydroxide solution at 100~110℃, and maintain the pH of the reaction solution=10~11. React at 110°C for 30min, add hydrochloric acid to neutralize to pH = 1-2, precipitate phenoxyacetic acid, cool and filter to obtain white solid product.

Uses

Fungicide; keratin exfoliative (to relieve and to soften calluses, corns, and other hard skin surfaces; applied as plasters, pads or in liquids).

Acetic acid, 2-phenoxy-: ACTIVE

Food additives -> Flavoring Agents

Flavoring Agents

Computed Properties

Molecular Weight:152.15
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:152.047344113
Monoisotopic Mass:152.047344113
Topological Polar Surface Area:46.5
Heavy Atom Count:11
Complexity:127
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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