5-FORMYL-2-THIOPHENECARBOXYLICACID

Bright red solid

The compound 25 (2 g, 12.8 mmol) was dissolved in 200 ml of mixture solvent (THF: H20=1 : 1) and HYDROLYZATION was conducted by adding KOH (1.1 g, 19.2 MMOL). After the completion of the reaction, THF was removed under reduced pressure. 4-phenylporphyrin (2g, 10.25mmol), 5-formylthiophene-2-carboxylic acid (2.08 g, 13.33 mmol), HATU (5.85 g, 15.38 mmol) was dissolved in DMF (30 mL).Stir at room temperature for 20 min, N, N-Diisopropylethylamine (6.62 g, 51.26 mmol) was added and the mixture was reacted at room temperature for 3 hours.Pour the reaction solution into water, stir for 10 minutes, and filter by suction.Made a brownish yellow solid 2.51g, The yield was 73.4%.

5-Formyl-2-thiophenecarboxylic acid is a thiophene derivative as immunomodulating agents useful in the treatment of autoimmune diseases.

Molecular Weight:156.16
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:155.98811516
Monoisotopic Mass:155.98811516
Topological Polar Surface Area:82.6
Heavy Atom Count:10
Complexity:157
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes