Ethylene glycol monomethyl ether acetate

118.13

118.13

1700761

203-772-9

I62493E04O

0476

1189

DTXSID2025553

Colorless liquid

2915390090

35.53000

-0.08

White Solid

1.0074 g/cm³ @ Temp: 19 °C

-65.1 °C

145 °C

111 °F

1.391

Miscible

Store below +30°C.

2 mmHg

4.07

Oral-Rat LD50: 3390 mg/kg; Oral-Mouse LD50: 3100 mg/kg

In case of fire, high temperature, oxidant is more flammable; burning produces irritating smoke

1.7-8.8%(V)

Pleasant odor

Henry's Law constant = 1.09X10-6 atm-cu m/mol at 25 °C (est)

Percent in saturated air: 0.31-0.60 at 25 °C|Conversion factors: 1 ppm is equivalent to 4.83 mg/cu m, 1 mg/L is equivalent to 207 ppm at 25 °C, 760 mm Hg|SOLIDIFIES AT -70 °C|1 mg/cu m = 0.20 ppm; 1 ppm = 4.91 mg/cu m. Sat concn 47 g/cu m at 20 °C|For more Other Experimental Properties (Complete) data for METHYL CELLOSOLVE ACETATE (6 total), please visit the HSDB record page.

Flammable. Water soluble. Reacts slowly in water to form acetic acid and methyl alcohol; the reaction is not violent.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

2-Methoxyethyl acetate|D: Other compounds that may form peroxides|Kelly

740 °F (USCG, 1999)|394 °C, 740 °F|380 °C

Lower 1.7%; Upper 8.2%|Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.

At 25 °C = 50.27 kcal/mole; at boiling point = 43.9 kcal/mole

III

3

UN 1189 3/PG 3

1

60-61-20/21/22

53-45

KL5950000

T

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Explosive when mixed with air

P201-P280-P308 + P313

H226-H302 + H312 + H332-H360FD

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|1. BY ABSORBING IT IN VERMICULITE, DRY SAND, EARTH OR SIMILAR MATERIAL & DISPOSING IN SECURED SANITARY LANDFILL. 2. BY ATOMIZING IN SUITABLE COMBUSTION CHAMBER.

Nitrates, strong oxidizers, alkalis & acids

European Chem Indust Ecol Tox Centre; The Toxicology of Ethylene glycol monoalkyl ethers and its Relevance to Man. (6/30/92)|Toxicity to Man of Ethylene glycol monoalkyl ethers. Cahiers de notes documentaires - Securite et hygiene du travail 2nd quarter (1983) p 215-30 (No 111, Note No 1422-111-83).

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon monoxide, may be formed when involved in fire. (USCG, 1999)|Flammable. Above 45 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501|H226 (39.6%): Flammable liquid and vapor [Warning Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 101 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H226: Flammable liquid and vapor [Warning Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P281, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P308+P313, P312, P314, P321, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501|P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P281, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P308+P313, P311, P314, P321, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501|P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P281, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Respirator Recommendations: Up to 1 ppm [Table#507]|Respirator Recommendations: Up to 2.5 ppm [Table#508]|For more Personal Protective Equipment (PPE) (Complete) data for METHYL CELLOSOLVE ACETATE (9 total), please visit the HSDB record page.|(See protection codes)

MODERATE /FIRE HAZARD/ WHEN EXPOSED TO HEAT OR FLAME; CAN REACT WITH OXIDIZING MATERIALS

LIMITS (% BY VOL): 1.5%-12.3%|Above 45 °C explosive vapour/air mixtures may be formed.|Explosive limits , vol% in air: 1.5 (at 93 °C) - 12.3 (at 93 °C)

To fight fire, use CO2, dry chemical.|If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW SUFFICIENT TIME...TO COMPLETELY CLEAR HOOD DUCTWORK. BURN PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN SUITABLE COMBUSTION CHAMBER. LIQ...SHOULD NOT BE ALLOWED TO ENTER CONFINED SPACE, SUCH AS SEWER, BECAUSE OF POSSIBILITY OF EXPLOSION.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|If...agitated or heated, or if skin contact is extensive & prolonged, it is advisable to protect personnel by enclosing process or providing local exhaust ventilation. Skin & eye protection should also be worn if possibility of such contact exists. ...ingestion /hazard/ can...be prevented by keeping them in properly labelled containers. /Glycols & derivatives/|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.|For more Preventive Measures (Complete) data for METHYL CELLOSOLVE ACETATE (9 total), please visit the HSDB record page.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for METHYL CELLOSOLVE ACETATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Irritation eyes, nose, throat.

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 25 ppm (120 mg/cu m). Skin Designation.

Recommended Exposure Limit: 10 Hr Time-Weighted avg: 0.1 ppm (0.5 mg/cu m); skin.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Separated from strong oxidants, strong bases and strong acids. Keep in the dark.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The vapour is mildly irritating to the eyes. The substance may cause effects on the bone marrow and central nervous system. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. Exposure far above the OEL could cause unconsciousness.

The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the bone marrow and blood. This may result in lesions of blood cells and kidney impairment. May cause toxicity to human reproduction or development.

NO open flames, NO sparks and NO smoking. Above 45 °C use a closed system, ventilation and explosion-proof electrical equipment.

AVOID ALL CONTACT!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or eye protection in combination with breathing protection.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylene glycol monomethey ether acetate is produced, as an intermediate or a final product, by process units covered under this subpart.

| 0 - Materials that, under emergency conditions, would offer no hazard beyond that of ordinary combustible materials.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.

INDOOR AIR: Methyl cellosolve acetate was detected in a sample of indoor air from an unspecified building in Northern Italy between 1983 and 1984 at a concentration of 4 ug/cu m(1).

moderately toxic

... The methyl and ethyl ethers of ethylene glycol, ie 2- methoxyethanol (2-ME) esters, 2-methoxyethyl acetate (2-MEA) and 2-ethoxyethyl acetate (2- EEA) ... are all stable, and are all miscible with (or in the case of 2-EEA very soluble in) water and miscible with a large number of organic solvents. ... The solubility of these glycol ethers in water and their relatively low vapor pressure could result in their build-up in water in the absence of degradation. However, degradation by microorganisms in soil, sewage sludge, and water appears to prevent this possibility. Atmospheric emissions resulting from the use of glycol ethers as evaporative solvents result in the greatest environmental exposure.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L. ... Effects on Experimental Animals and In Vitro Test Systems: Systemic toxicity: The toxicity of 2-ME and 2-EE to experimental animals has been much more widely studied than that of 2-MEA and 2-EEA. 2-ME and 2-EE and their acetates have similar lethalities after single exposures and they show low acute lethality whether exposure is via the dermal, oral, or inhalation route. Oral LD60 values for a variety of species range between 900 and 3400 mg/kg body weight for 2-ME, 1400 and 5500 mg/kg for 2-EE, 1250 and 3930 mg/kg for 2-MEA, and 1300 and 5100 mg/kg for 2-EEA. ... Short-term inhalation exposure (up to 90 days) of experimental animals to high concentrations (> 9313 mg 2-ME/cu m ... has been shown to lead to adverse effects on blood parameters, the nervous system, and testes, thymus, kidney, liver, and lung. At lower exposure levels, effects are observed on the hemopoietic system and testes. For example, rats exposed by inhalation to 2-ME for 13 weeks at levels between 93 and 930 mg/cu m exhibited reduced packed cell volume and white blood cell, hemoglobin, platelet, and serum protein concentrations at the highest dose only, while similarly exposed rabbits had decreased thymus size, in addition to the decreased blood parameters, at 930 mg/cu m. ... The mutagenicity of 2-ME has been investigated in a range of in vitro systems using bacteria and mammalian cells. Although most studies yielded negative results, there were reports of positive mutagenicity results at very high 2-ME concentrations in CHO cells when investigated for chromosome aberration (at 6830 ug/mL or more) and sister chromatid exchange (3170 ug/mL or more). However, in vivo studies for chromosome aberrations and micronuclei were negative. ... The effect of 2-ME on the male reproductive system has been intensively investigated following both oral and inhalation exposure in rodents. Degenerative changes in the germinal epithelium of the seminiferous tubules were consistently noted. ... Oral dosing of rats with 2-ME for 1-11 days resulted in a dose-related decrease in sperm count and changes in sperm motility and morphology at dose levels of 100 mg/kg body weight or more. Marked histological damage was seen in the testes at autopsy. The no-observed-effect level (NOEL) was 50 mg/kg. Reduced fertility was still evident 8 weeks after exposure to 200 mg/kg. ... Fertility studies following a single oral dose of 250 mg 2-ME/kg or more revealed complete sterility in both rats and mice at 5 weeks post dosing, some decrease in fertility being seen at 125 mg/kg. When the inhalation route was investigated, similar degenerative changes in the testes were seen with 2-ME. Effects were observed following a single exposure (4 hr) to 1944 mg/m3 or more but not to 933 mg/cu m. NOEL values were 311 mg/cu m in rats following exposure for 13 weeks (6 hr/day, 5 day/week) and 933 mg/cu m (6 hr/day) in mice following exposure on 9 occasions over 11 days. Exposure of rabbits to 2-ME for 13 weeks (6 hr/day, 5 days/week) resulted in marked effects on the testes at 311 mg/cu m or more; marginal effects were seen at 93 mg/cu m, and a NOEL was not identified. ... Developmental toxicity has been observed in several species of laboratory animals following exposure by all routes of administration, i.e. oral, inhalation, and dermal. 2-ME produced teratogenic effects in mice, rats, rabbits, and monkeys. ... Although 2-MEA has not been tested for developmental toxicity, metabolic profiles suggest that it is reasonable to expect that 2-MEA would have a toxicity similar to that of 2-ME. The widest range of dose/response data (doses of 31.25 to 1000 mg/kg per day) is available for 2-ME. In this gavage study using mice, (2-ME was administered on days 7 to 14 of gestation), the NOEL for maternal toxicity was 125 mg/kg per day. However, malformations were observed at 62.5 mg/kg per day and skeletal variations at 31.25 mg/kg per day. A NOEL for developmental toxicity was not reported. In single-dose studies, mice were treated with 2-ME by gavage on gestation day 11; 100 mg/kg was not fetotoxic, while 175 mg/kg produced digit defects without other signs of maternal or fetal toxicity. Cardiovascular defects and ECG abnormalities were observed in neonatal rats following treatment on days 7 to 13 of gestation with 25 mg/kg per day. Since that was the lowest dose tested, this study yielded no developmental NOEL (maternal toxicity was not observed at that dose). Similarly, no NOEL for developmental toxicity could be determined when monkeys were treated by gavage with 2-ME at 0.16, 0.32, or 0.47 mmol/kg per day on days 20 to 45 of gestation. Fetotoxicity in mice and rats and malformations in rabbits were observed following exposure by inhalation to 2-ME at 156 mg/m3. For all three species, the NOEL for developmental effects was 31 mg/cu m. However, behavioral and neurochemical alterations were seen in the offspring of rats exposed to 78 mg 2-ME/cu m on days 7-13 or 14-20 of gestation. Following inhalation exposure of rats (743 mg/m3) and rabbits (589 mg/m3), 2-EE was found to be teratogenic (in the presence of slight maternal toxicity). ... Information on the toxic effects of these four glycol ethers on humans is limited. The results from the few case reports and workplace epidemiological studies are consistent with the adverse effects seen in experimental animals. ...

LD50 Rat oral 3.93 g/kg|LD50 Rat oral 1.25 g/kg|LD50 Guinea pig oral 1.25 g/kg|LD50 Rabbit oral 0.5 or 1.0 mL/kg|For more Non-Human Toxicity Values (Complete) data for METHYL CELLOSOLVE ACETATE (11 total), please visit the HSDB record page.

/AQUATIC SPECIES/ Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L ...

Methyl cellosolve acetate's production and use as a solvent for nitrocellulose, cellulose acetate, various gums, resins, waxes, oils; in textile printing; photographic film; lacquers; and dopes(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from an estimated log Kow of 0.10(2) and a regression-derived equation(3), indicates that methyl cellosolve acetate is expected to have very high mobility in soil(SRC). Volatilization of methyl cellosolve acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg at 20 °C(4), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(5). The potential for volatilization of methyl cellosolve acetate from dry soil surfaces may exist(SRC) based on its vapor pressure(4). Using aqueous screening tests methyl cellosolve acetate reached 30 to 86.9% of its theoretical BOD over a period of 5 to 14 days(6,7), suggesting that biodegradation may be an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from an estimated log Kow of 0.10(2) and a regression-derived equation(3), indicates that methyl cellosolve acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg(4), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 24 days and 270 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3.2(3), from an estimated log Kow(2), and a regression derived equation(7) suggests that bioconcentration in aquatic organisms is low(SRC). Hydrolysis half-lives of 140 and 14 days at pH values of 7 and 8, respectively(10), suggest that hydrolysis is not expected to be an important process except under basic conditions(SRC). Using aqueous screening tests, methyl cellosolve acetate reached 30 to 86.9% of its theoretical BOD over a period of 5 to 14 days(8,9), suggesting that biodegradation may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl cellosolve acetate, which has a measured vapor pressure of 7.0 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl cellosolve acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 1.1 days(SRC) calculated from its rate constant of 9.7X10-12 cu cm/molecule-sec at 25 °C(SRC)that was derived using a structure estimation method(3). Methyl cellosolve acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of methyl cellosolve acetate with photochemically-produced hydroxyl radicals has been estimated as 9.7X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.1 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.263 L/mol-sec(SRC) was measured for methyl cellosolve acetate(2); this corresponds to half-lives of 140 and 14 days at pH values of 7 and 8, respectively(2). Methyl cellosolve acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3.2 was calculated for methyl cellosolve acetate(SRC), using an estimated log Kow of 0.10(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of methyl cellosolve acetate is estimated as approximately 30(SRC), using an estimated log Kow of 0.10(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that methyl cellosolve acetate is expected to have very high mobility in soil(SRC).

The Henry's Law constant for methyl cellosolve acetate is estimated as 1.1X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0 mm Hg at 20 °C(1), and assigned value for water solubility of 1.0X10+6 mg/L (miscible)(2). This value indicates that methyl cellosolve acetate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 24 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 270 days(SRC). The Henry's Law constant of methyl cellosolve acetate indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of methyl cellosolve acetate from dry soil surfaces may exist(SRC) based on its measured vapor pressure(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 9,982 workers (2,801 of these were female) were potentially exposed to methyl cellosolve acetate in the US(1). Occupational exposure to methyl cellosolve acetate may occur through inhalation and dermal contact with this compound at workplaces where methyl cellosolve acetate is produced or used(SRC).|The geometric mean concentration of methyl cellosolve acetate obtained during personal sampling of workplace air, 16 personal air samples of 4 to 8 hours duration from seven different companies during the manufacture of wafers, was 0.01 ppm(1). 5 of 111 personal air samples collected in silk-screen printing installations contained methyl cellosolve acetate at a mean concentration of 0.8 mg/cu m(2).|ENVIRONMENTAL INVESTIGATIONS WERE CONDUCTED TO EVALUATE EXPOSURE TO MATERIALS USED BY ARTISTS & CRAFTMEN. EXPOSURES TO METHYL CELLUSOLVE ACETATE ARE POTENTIALLY TOXIC AT CONCN MEASURED DURING EVALUATION.|Exposure in an automobile body shop ... .

... Can be absorbed via the skin, lungs or GI tract.

...Must be .../hydrolyzed/ by body because it gives rise to toxic signs similar to those caused by ethylene glycol methyl ether. Some acetaldehyde may also be formed.|The ester hydrolyzes in body to 2-methoxyethanol.|EGMEA is readily metabolized in mouse nasal tissues to produce EGME. EGME is further metabolized by alcohol dehydrogenase to 2-methoxyacetic acid, a known reproductive and developmental toxicant.|The in vitro nasal mucosal carboxylesterase activity of mice was compared to the activity of other mice tissues and to the nasal mucosal carboxylesterase activity of rats, rabbits, or dogs when exposed to 2-MEA or 2-EEA. The specific activity in nasal carboxylase was found to be similar to that of the liver in mice, but it was greater than the activity found in the kidney, lung, or blood of mice. Nasal mucosal carboxyl-esterase activity of mice was comparable to that of dogs, slightly higher than the activity in rats, and nearly six-fold higher than the activity in rabbits. These in vitro studies suggest that considerable hydrolysis may occur in the intact animal, resulting in the formation of acetic acid at the initial route of entry.

May cause irritation if splashed into eyes. Can be absorbed through the skin. Swallowing a large single dose or absorbing larged amount through skin could result in death. It is unlikely that air levels of the compound would be dangerous unless it is heated. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ethylene glycol, glycols, and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ethylene glycol, glycols, and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ethylene glycol, glycols, and related compounds/

/SIGNS AND SYMPTOMS/ Symptomatology B) ... 3. Nausea, vomiting and sometimes diarrhea. 4. Prominent headache. Later abdominal and lumbar pain and costovertebral angle tenderness. 5. Transient polyuria and then oliguria, progressing to anuria. 6. Acute renal failure with uremia, peripheral edema, ascites, pulmonary edema, drowsiness, cyanosis, coma and death in 7-10 days. 7. Less critical pathological lesions may appear in brain, lungs, liver, meninges and heart. /Ethylene glycol/|/SIGNS AND SYMPTOMS/ Blood disorders, CNS effects/ kidney damage|/SIGNS AND SYMPTOMS/ Ethylene glycol monomethyl ether acetate (EGMEA) has low single-dose oral toxicity, is not significantly irritating to the eyes or skin, is poorly absorbed through the skin, and is moderately toxic when inhaled. Its effects are similar to those of ethylene glycol monomethyl ether and are centered in the blood, kidneys, brain, and testes.|/SIGNS AND SYMPTOMS/ Effects on the central nervous system are the most prominent features of 2-methoxyethanol intoxication. Metabolic acidosis and kidney damage have been seen after acute ingestion and anemia has resulted from prolonged exposure to high vapor concentration in the workplace. /2-Methoxyethanol/|For more Human Toxicity Excerpts (Complete) data for METHYL CELLOSOLVE ACETATE (13 total), please visit the HSDB record page.

2-methoxyethanol acetate

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, nose, throat; kidney, brain damage; In Animals: narcosis; reproductive, teratogenic effects

Dizziness. Drowsiness. Headache.

MAY BE ABSORBED! Dry skin. Further see Inhalation.

Redness.

Eyes, respiratory system, kidneys, brain, central nervous system, peripheral nervous system, reproductive system, hematopoietic system

Ethanol, 2-methoxy-, 1-acetate: ACTIVE|S - indicates a substance that is identified in a final Significant New Use Rule.

NIOSH Method S39-1. Analyte: Methyl cellosolve acetate. Matrix: Air. Procedure: GC. Method Evaluation: Method was validated over the range of 51 to 214 mg/cu m using a 20 liter sample. Method detection limit: Not determined. Precision (CVT): 0.0675. Applicability: Under the conditions of sample size (20 liters) the useful range is 12 to 360 mg/cu m. Interferences: No specific interferences.|Determination of 2-methyoxyethyl acetate concn in workplace air by GC.|Method: NIOSH 1451, Issue 2; Procedure: gas chromatography with flame ionization detector; Analyte: methyl cellosolve acetate; Matrix: air; Detection Limit: 10 ug per sample.|Method: OSHA 79; Procedure: gas chromatography using a flame ionization detector; Analyte: 2-methoxyethyl acetate; Matrix: air; Detection Limit: 1.7 ppb (8.4 ug/cu m).

Fire Hazards -> Flammable - 2nd degree