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Home > Encyclopedia > 4-Quinolinamine, N-hydroxy-, 1-oxide

4-Quinolinamine, N-hydroxy-, 1-oxide

4-Quinolinamine, N-hydroxy-, 1-oxide structure

4-Quinolinamine, N-hydroxy-, 1-oxide 

structure
  • CAS No:

    4637-56-3

  • Formula:

    C9H8N2O2

  • Chemical Name:

    4-Quinolinamine, N-hydroxy-, 1-oxide

  • Synonyms:

    4-Quinolinamine,N-hydroxy-,1-oxide;Quinoline,4-(hydroxyamino)-,1-oxide;4-Hydroxylaminoquinoline 1-oxide;4-(Hydroxyamino)quinoline 1-oxide;4-Hydroxyaminoquinoline N-oxide;4-Hydroxylaminoquinoline N-oxide;NSC 177384;362-26-5

  • Categories:

    Chemical Reagents  >  Organic Reagents

Description

Gold -colored granular solid. (NTP, 1992)


Gold -colored granular solid. (NTP, 1992)|A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.

4-Quinolinamine, N-hydroxy-, 1-oxide Basic Attributes

176.17

176.17

DTXSID3025419

2933499090

Characteristics

57.72000

0.00

Gold -colored granular solid. (NTP, 1992)

1.4±0.1 g/cm3

210 °C (decomp) (approx)

425.6±55.0 °C at 760 mmHg

211.2±31.5 °C

1.651

less than 1 mg/mL at 68° F (NTP, 1992)

Insoluble in water.

Amines, Phosphines, and Pyridines

4-QUINOLINAMINE-N-HYDROXY-1-OXIDE is a weak oxidizing agent.

Safety Information

45-46-25-37/38-41-68

53-26-36/37/39-45

VB9800000

T

|Danger|H301 (97.44%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P309+P311, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Drug Information

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)|Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

4 Hydroxyaminoquinoline 1 oxide

Computed Properties

Molecular Weight:176.17
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Exact Mass:176.058577502
Monoisotopic Mass:176.058577502
Topological Polar Surface Area:56.1
Heavy Atom Count:13
Complexity:250
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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