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Trichodermin

Trichodermin structure

CAS No:
4682-50-2
Formula:
C17H24O4
Chemical Name:
Trichodermin
Synonyms:
Trichothec-9-en-4-ol,12,13-epoxy-,acetate,(4β)-;Trichodermin;Trichothec-9-en-4β-ol,12,13-epoxy-,acetate;Spiro[2,5-methano-1-benzoxepin-10,2′-oxirane],trichothec-9-en-4-ol deriv.;WG 696;NSC 267033;NSC 73846;11010-11-0;16821-99-1
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ChEBI: A tetracyclic spiroepoxide which acts as an antifungal and protein synthesis inhibitor.

Antifungal metabolite from several fungi, mainly Trichoderma viride; inhibits protein synthesis by binding to ribosomes; proposed as antifungal and antineoplastic; used as tool in cellular biochemistry.

Trichodermin Basic Attributes

Molecular Weight：

292.37000

Exact Mass：

292.37

UNII：

WF22557W91

Characteristics

PSA：

48.06000

XLogP3：

2.61090

Density：

1.19g/cm3

Melting Point：

45-46 °C

Boiling Point：

371.2ºC at 760 mmHg

Flash Point：

161ºC

Refractive Index：

1.545

Toxicity：

LD50 in mice (mg/kg): 500-1000 s.c.; >1000 orally ( NL 302527 )

Drug Information

MeSH Entry Terms：

Trichodermin

Computed Properties

Molecular Weight:292.4
XLogP3:1.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:292.16745924
Monoisotopic Mass:292.16745924
Topological Polar Surface Area:48.1
Heavy Atom Count:21
Complexity:541
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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4682-50-2

CAS No.: 4682-50-2

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