HC Yellow 2

Orange crystal powder

In a 1 L three-necked flask, 100 g of , o-chloronitrobenzene 450 g of n-hexane and 10 g of sodium fluoride were successively added and the temperature was raised to 80 ° C, 60 g of ethanolamine was added dropwise, and the reaction was carried out at this temperature for 20 hours. Sampling analysis, control the HPLC content of raw materials less than 3percent That is to stop the reaction. 90 ° C under reduced pressure distillation of petroleum ether, adding methanol and water for crystallization, filtration, washing, drying to get red Color crystal powder N- (2-nitrophenyl) ethanolamine 103g, HPLC purity 99.6percent2-fluoronitrobenzene (0.92 g, 6.53 mmol) and ethanolamine (1.19 g, 19.59 mmol) were dissolved in 20 mL ethanol, potassium carbonate (1.08 g, 7.83 mmol) was added and stirred under reflux for 5-6 hours, after the reaction solution was cooled, filtered, the filtrate was concentrated under reduced pressure, to obtain an orange solid, and 20 mL saturated brine was added, extracted with ethyl acetate (3×40 mL), the organic phases were combined, washed with a saturated brine, dried on anhydrous sodium sulfate, rotary evaporated, purified by silica gel column chromatography to obtain 2-nitro-N-(2-hydroxyethyl)aniline (0.98 g, yield 82.9percent).In a 1 L three-necked flask, 100 g of , o-chloronitrobenzene 450 g of n-hexane and 10 g of sodium fluoride were successively added and the temperature was raised to 80 ° C, 60 g of ethanolamine was added dropwise, and the reaction was carried out at this temperature for 20 hours. Sampling analysis, control the HPLC content of raw materials less than 3percent That is to stop the reaction. 90 ° C under reduced pressure distillation of petroleum ether, adding methanol and water for crystallization, filtration, washing, drying to get red Color crystal powder N- (2-nitrophenyl) ethanolamine 103g, HPLC purity 99.6percent2-fluoronitrobenzene (0.92 g, 6.53 mmol) and ethanolamine (1.19 g, 19.59 mmol) were dissolved in 20 mL ethanol, potassium carbonate (1.08 g, 7.83 mmol) was added and stirred under reflux for 5-6 hours, after the reaction solution was cooled, filtered, the filtrate was concentrated under reduced pressure, to obtain an orange solid, and 20 mL saturated brine was added, extracted with ethyl acetate (3×40 mL), the organic phases were combined, washed with a saturated brine, dried on anhydrous sodium sulfate, rotary evaporated, purified by silica gel column chromatography to obtain 2-nitro-N-(2-hydroxyethyl)aniline (0.98 g, yield 82.9percent).

Mainly used in the synthesis of dyes and hair dyes

Molecular Weight:182.18
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:182.06914219
Monoisotopic Mass:182.06914219
Topological Polar Surface Area:78.1
Heavy Atom Count:13
Complexity:169
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes